Results 91 to 100 of about 3,700,495 (306)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Comparative analysis of surgical effectiveness between minimal invasive decompression and transforaminal lumbar interbody fusion in lumbar stenosis treatment

Brain and Spine, 2021
E. Brinyuk, N. Konovalov, A. Nazarenko, S. Kaprovoy, D. Asyutin, M. Shultz, R. Onoprienko, V. Korolishin, B. Zakirov, P. Zelenkov, A. Pogosyan, V. Rybakov   +11 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Comparison of the efficacy and safety of the posterior and paramedian minimally invasive approaches to ventral and ventro-lateral intradural extramedullary tumors

Brain and Spine, 2021
D. Asyutin, N. Konovalov, A. Nazarenko, R. Onoprienko, V. Korolishin, S. Kaprovoy, E. Brinyuk, A. Pogosyan, S. Timonin, B. Zakirov, M. Shultz, Y. Poluektov   +11 more
doaj   +1 more source

Intraoperative 3D Navigation‐Guided Resection of Enlarged Transverse Process for Treating Bertolotti Syndrome Unresponsive to Noninvasive Treatments: Case Report

Clinical Case Reports
Bertolotti syndrome is a lumbosacral anomaly that induces persistent lumbar pain. This case describes 3D navigation‐guided resection of an enlarged transverse process.
Jakub Jankowski, Marcin Glin, Natalia Maślanek, Wiktoria Chyra, Agnieszka Pawełczyk, Maciej Radek   +5 more
doaj   +1 more source

Management of peripheral ossifying fibroma due to severe periodontitis: Case report [PDF]

Balkan Journal of Dental Medicine
Background/Aim: Peripheral ossifying fibroma (POF) constitutes a common reactive lesion of the gingiva, most commonly localized in the anterior maxillary region.
Zisis Stefanos, Zisi Vasileios, Shinas Nikolaos, Poulopoulos Konstantinos, Charisi Christina, Papadopoulos Petros, Kyriakou Nikolaos, Cordahi Joe, Anagnostou Eleftherios, Poulopoulos Athanasios   +9 more
doaj   +1 more source

Peripheral Nerve [PDF]

Operative Neurosurgery, 2019
Robert J, Spinner, Amgad S, Hanna, Andrés A, Maldonado, Thomas J, Wilson   +3 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Advances in Stem Cell Therapy for Diabetic Foot Ulcers

Diabetes, Metabolic Syndrome and Obesity
Bin Wang,1,2 Gang Zhao,2,3 Jiaqi Zhang,4 Wenyu Chen,2 Shanshan Yang,1 Yinuo Sun1 1Department of Surgery, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China ...
Wang B, Zhao G, Zhang J, Chen W, Yang S, Sun Y   +5 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source