Results 121 to 130 of about 1,864,506 (312)
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
Journal of Family and Community Medicine, 2018 OBJECTIVE: The aim of this study was to assess the prevalence of painful diabetic peripheral neuropathy (PDPN) and its associated risk factors in patients with type 2 diabetes mellitus attending primary health care (PHC) in Saudi Arabia.
Metab A Algeffari
doaj +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. [PDF]
, 1995 Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T cells was associated with mutations in ZAP-70.
Gelfand, EW +4 more
core
Annals of Indian Academy of Neurology, 2011 Background: Rheumatoid arthritis is a multi-system autoimmune disorder predominantly involving multiple small and large joints along with certain extra-articular manifestations.
Monodeep Biswas +5 more
doaj +1 more source
Peripheral convex expansions of resonance graphs [PDF]
arXiv, 2019 In this paper, we show that the resonance graph of a plane elementary bipartite graph $G$ can be obtained from an edge by a sequence of peripheral convex expansions with respect to a reducible face decomposition of $G$ if and only if the infinite face of $G$ is forcing.
arxiv
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Modeling the Contribution of Central Versus Peripheral Vision in Scene, Object, and Face Recognition [PDF]
, 2016 It is commonly believed that the central visual field is important for recognizing objects and faces, and the peripheral region is useful for scene recognition.
Cottrell, Garrison, Wang, Panqu
core +1 more source
The Function of MicroRNAs in B-Cell Development, Lymphoma, and Their Potential in Clinical Practice
Frontiers in Immunology, 2018 B-cell formation, development, and differentiation are complex processes regulated by several mechanisms. Recently, there has been growing evidence indicating that microRNAs (miRNAs) are important for normal B-cell lineage development.
Bing Zheng +13 more
doaj +1 more source