Results 61 to 70 of about 33,898 (192)

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo   +10 more
wiley   +1 more source

The effect of exercise training on endothelial function in postmenopausal women with breast cancer under aromatase inhibitor therapy

open access: yesCancer Medicine, Volume 11, Issue 24, Page 4946-4953, December 2022., 2022
Exercise training led to significantly greater improvement in exercise capacity in postmenopausal women with aromatase inhibitor‐treated breast cancer than exercise counseling only, none the less it did not exert any measurable effects on endothelial dysfunction Abstract Background Breast cancer is the leading non‐cardiovascular cause of death in women.
Barbara Mayr   +3 more
wiley   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

open access: yesAdvanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang   +13 more
wiley   +1 more source

Is plantar thermography a valid digital biomarker for characterising diabetic foot ulceration risk? [PDF]

open access: yesarXiv
Background: In the absence of prospective data on diabetic foot ulcers (DFU), cross-sectional associations with causal risk factors (peripheral neuropathy, and peripheral arterial disease (PAD)) could be used to establish the validity of plantar thermography for DFU risk stratification.
arxiv  

Comparison of Clinical Scores for Predicting Stroke‐Associated Pneumonia After Acute Ischemic Stroke

open access: yesAGING MEDICINE, EarlyView.
Our study compared the discrimination and calibration of the Kwon Pneumonia Score, A2DS2 score, PANTHERIS score, AIS‐APS score, ISAN score, and PASS score in SAP identification; of these, the AIS‐APS score showed the best performance. ABSTRACT Objectives To compare the discrimination and calibration of six risk scoring systems in the assessment of ...
Linlin Wang   +8 more
wiley   +1 more source

Long‐term outcomes after paclitaxel‐coated balloon angioplasty of femoropopliteal arteries in Asian patients of the IN.PACT Global Study

open access: yesCatheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1273-1283, December 1, 2022., 2022
Abstract Objectives The long‐term data on the use of drug‐coated balloons (DCBs) for femoropopliteal atherosclerotic lesions in the real‐world setting are limited, even more so for racially and geographically distinct populations. The present analysis reports the 5‐year safety and effectiveness outcomes of a DCB in the Asian subset of the prospective ...
Young‐Guk Ko   +7 more
wiley   +1 more source

Utilizing AI Language Models to Identify Prognostic Factors for Coronary Artery Disease: A Study in Mashhad Residents [PDF]

open access: yesarXiv
Abstract: Background: Understanding cardiovascular artery disease risk factors, the leading global cause of mortality, is crucial for influencing its etiology, prevalence, and treatment. This study aims to evaluate prognostic markers for coronary artery disease in Mashhad using Naive Bayes, REP Tree, J48, CART, and CHAID algorithms.
arxiv  

Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease. [PDF]

open access: bronze, 1989
M.R. Malinow   +8 more
openalex   +1 more source

Risk Factors and Predictive Model for Ischemic Complications in Endovascular Treatment of Intracranial Aneurysms: Insights From a Large Patient Cohort

open access: yesAGING MEDICINE, EarlyView.
Independent risk factors for ischemic complications in endovascular treatment of intracranial aneurysms were identified using machine learning methods, and the first prediction model for ischemic complications of all intracranial aneurysms was constructed. Moreover, the model showed a stable and excellent predictive efficacy.
Jianwen Jia   +6 more
wiley   +1 more source

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