Results 111 to 120 of about 287,339 (268)

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

ASSOCIATION BETWEEN IT-HOSPITAL MORTALITY AND NON-SURGICAL COMPLICATIONS AFTER OPERATION IN LOWER LIMB AMPUTATION DUE TO PERIPHERAL ARTERY DISEASE

Медицина в Кузбассе, 2018
Objective – to investigate the structure of non-surgical complications after operation, define its effect on in-hospital mortality in lower limb amputations in patients with peripheral artery disease. Materials.
Денис Николаевич Макаров, Елена Михайловна Васильченко   +1 more
doaj  

Serum 25-hydroxyvitamin D is associated with incident peripheral artery disease among white and black adults in the ARIC study cohort

, 2017
Ian Rapson, Erin D. Michos, Álvaro Alonso, Alan T. Hirsch, Kunihiro Matsushita, Jared P. Reis, Pamela L. Lutsey   +6 more
openalex   +2 more sources

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, EarlyView.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

Relation between the ankle-brachial index and the complexity of coronary artery disease in older patients

Clinical Interventions in Aging, 2013
Felipe José de Andrade Falcão,1 Cláudia Maria Rodrigues Alves,1 Adriano Caixeta,1 Leonardo de Freitas Guimarães,1 Juscélio Trajano de Sousa Filho,2 Juliana A Soares,2 Izo Helber,2 Antônio C Carvalho11Department of
Falcão FJ, Alves CM, Caixeta A, Guimarães LF, Sousa Filho JT, Soares JA, Helber I, Carvalho AC   +7 more
doaj  

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors [PDF]

, 2017
Lung‐An Hsu, Semon Wu, Jyh‐Ming Jimmy Juang, Fu‐Tien Chiang, Ming‐Sheng Teng, Jeng-Feng Lin, Hsuan‐Li Huang, Yu‐Lin Ko   +7 more
openalex   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

Impact of Food and Drug Administration Safety Communications on Drug-coated Device Utilization in Peripheral Artery Disease [PDF]

Midori P. White, Chen Dun, YH Andrew Wu, Jamie Schwartz, Jesse A. Columbo, Christopher J. Abularrage, Ying Wei Lum, James H. Black, Caitlin W. Hicks   +8 more
openalex   +1 more source