Results 141 to 150 of about 287,339 (268)

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science, EarlyView.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
wiley   +1 more source

Trends and disparities in mortality associated with peripheral artery disease and hyperlipidemia, 1999-2024. [PDF]

Sci Rep
Khan S, Hassan M, Hussain M, Dhedhi HAA, Fatima W, Nawaz J, Ahsan A, Pirih FNU, Khalid N, Qaisar M, Qureshi AA, Baig M, Eltawansy S, Afridi MK, Memon P, Waqas SA, Fonarow GC, Ahmed R, Aminpoor H.   +18 more
europepmc   +1 more source

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
ABSTRACT The blood‐brain barrier (BBB) renders the delivery of nanomedicine in the brain ineffective and the detection of circulating disease‐related DNA from the brain unreliable. Here, we demonstrate that microbubble‐enhanced focused ultrasound (MB‐FUS) mediated BBB opening, supported by large‐data models predict sonication regimens for safe and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

Genetic Insights into Peripheral Artery Disease: A Narrative Review. [PDF]

Biomedicines
Pérez-Hernández N, Rodríguez-Pérez JM, Nicanor-Juárez LE, Torres-Machorro A, García-Alva JR, Villamil-Castañeda C, Borgonio-Cuadra VM, Flores-García M.   +7 more
europepmc   +1 more source

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

C-reactive protein-to-albumin ratio in peripheral artery disease. [PDF]

Open Med (Wars)
Saputra PBT, Purwati DD, Oktafia P, Kurniawan RB, Savitri CG, Putranto JNE, Multazam CECZ, D'Oria M, Alkaff FF.   +8 more
europepmc   +1 more source

GLOBAL TRENDS OF MORTALITY IN PERIPHERAL ARTERY DISEASE (PAD) PATIENTS: A COMPARATIVE STUDY OF THE USA AND EUROPE CONSIDERING SMOKING AND METABOLIC RISK FACTORS FROM THE GLOBAL BURDEN OF DISEASE REGISTRY-1990 TO 2021

Vidit Majmundar, Warren Fernandes, Amir Joshi, Bolivia Fernandes, Shreyash Parajuli, Pengyang Li, Sourbha S. Dani   +6 more
openalex   +1 more source

Images in cardiovascular medicine. Untreated gangrene in patients with peripheral artery disease. [PDF]

, 1994
Jeffrey M. Isner, Ann Pieczek, Ken Rosenfield   +2 more
openalex   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source