Results 221 to 230 of about 298,696 (311)

Peripheral Blood Mononuclear Cells Profiling Revealed Biomarkers That Predict PD-1 Inhibitor-Induced Immune-Related Adverse Events. [PDF]

MedComm (2020)
Wang J, Xie H, Gong Y, Liu S, Guan Y, Zhang Y, Xie Q, Wang J, Li Y, Zeng X, Chen X, Wang C.   +11 more
europepmc   +1 more source

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

Iron, arginine, and redox metabolism in peripheral blood mononuclear cells distinguishes sickle cell disease and pulmonary hypertension. [PDF]

Hemasphere
Cendali FI, Lisk C, Argabright A, Dzieciatkowska M, Rana NK, Swindle D, Stephenson D, McAfee J, Westover N, Lucero M, Gandjeva A, Stenmark K, Tuder R, Graham BB, Lahm T, Karoor V, George G, Hassel K, Nuss R, Davizon-Castillio P, Buehler PW, D'Alessandro A, Irwin DC.   +22 more
europepmc   +1 more source

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Overexpression of ITGB3 in Peripheral Blood Mononuclear Cells of Relapsing-Remitting Multiple Sclerosis Patients. [PDF]

Int J Mol Sci
Sancho GBV, Buendia-Corona RE, Reyes-Mata MP, Mireles-Ramírez MA, Griñán-Ferré C, Pallàs M, Márquez-Aguirre AL, Pavon L, Arias-Carrión O, Guerrero-García JJ, Ortuño-Sahagún D.   +10 more
europepmc   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Profiling cell dynamic changes of goat peripheral blood mononuclear cells after Pasteurella multocida infection with single-cell transcriptomics and histopathology. [PDF]

Vet Res
An Q, Chen T, Jiang J, Wu H, Wu G, Jiao Z, Li S, Meng Y, Tang J, Chen Y, Pan H, Li H, Zhang Z, Cheng Y, Fu Y, Huang Z, Manchu R, Chen Q, Wang F.   +18 more
europepmc   +1 more source

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Single-cell transcriptomic profiling of peripheral blood mononuclear cells reveals monocyte heterogeneity in patients with Moyamoya disease. [PDF]

Orphanet J Rare Dis
Xiao J, Wei L, Qiu X, Yan J, Li Y, Wu J, Miu H, Zhang S, Luo D, Zeng E.   +9 more
europepmc   +1 more source