Results 1 to 10 of about 128,249 (313)

Identification of Key Genes and Pathways in Peripheral Blood Mononuclear Cells of Type 1 Diabetes Mellitus by Integrated Bioinformatics Analysis [PDF]

Diabetes & Metabolism Journal, 2022
Background The onset and progression of type 1 diabetes mellitus (T1DM) is closely related to autoimmunity. Effective monitoring of the immune system and developing targeted therapies are frontier fields in T1DM treatment.
Xing Li, Mingyu Liao, Jiangheng Guan, Ling Zhou, Rufei Shen, Min Long, Jiaqing Shao   +6 more
doaj   +1 more source

Enhanced serum interferon-lambda 1/interleukin-29 levels in patients with psoriasis vulgaris

Anais Brasileiros de Dermatologia, 2021
Background: Interferon (IFN)-λ1, also named Interleukin (IL)-29, is a new member of the Type III IFN or IFN-λ family. IL-29 plays an important role in the pathogenesis of many types of autoimmune and inflammatory diseases.
Li-xin Fu, Tao Chen, Zai-Pei Guo, Na Cao, Li-Wen Zhang, Pei-Mei Zhou   +5 more
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Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study. [PDF]

PLoS ONE, 2014
Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure.
Lyle R McKinnon, Sean M Hughes, Stephen C De Rosa, Jeffrey A Martinson, Jill Plants, Kirsten E Brady, Pamela P Gumbi, Devin J Adams, Lucia Vojtech, Christine G Galloway, Michael Fialkow, Gretchen Lentz, Dayong Gao, Zhiquan Shu, Billy Nyanga, Preston Izulla, Joshua Kimani, Steve Kimwaki, Alfred Bere, Zoe Moodie, Alan L Landay, Jo-Ann S Passmore, Rupert Kaul, Richard M Novak, M Juliana McElrath, Florian Hladik   +25 more
doaj   +1 more source

Antipsychotics preserve telomere length in peripheral blood mononuclear cells after acute oxidative stress injury

Neural Regeneration Research, 2022
Antipsychotics may prolong or retain telomere length, affect mitochondrial function, and then affect the metabolism of nerve cells. To validate the hypothesis that antipsychotics can prolong telomere length after oxidative stress injury, leukocytes from ...
Gabriel B Polho, Giancarlo M Cardillo, Daniel S Kerr, Thais Chile, Wagner F Gattaz, Orestes V Forlenza, Helena P Brentani, Vanessa J De-Paula   +7 more
doaj   +1 more source

TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells

Arthritis Research & Therapy, 2023
Background Soluble urate leads to a pro-inflammatory phenotype in human monocytes characterized by increased production of IL-1β and downregulation of IL-1 receptor antagonist, the mechanism of which remains to be fully elucidated.
Viola Klück, Georgiana Cabău, Linda Mies, Femke Bukkems, Liesbeth van Emst, René Bakker, Arjan van Caam, HINT consortium, Tania O. Crişan, Leo A. B. Joosten   +9 more
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DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis

Frontiers in Pediatrics, 2020
Background: Histological chorioamnionitis (HCA) is an infection/inflammation of fetal membranes and complicates 5.2–28.5% of all live births. Exposure to HCA can have long-term consequences including abnormal neurodevelopment and an increased risk for ...
Gina Fong, Suhita Gayen nee' Betal, Swati Murthy, Michael Favara, Joanna S. Y. Chan, Sankar Addya, Thomas H. Shaffer, Jay Greenspan, Vineet Bhandari, Dongmei Li, Irfan Rahman, Zubair H. Aghai   +11 more
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Histological assessment of the efficiency of rabbit serum in healing skin wounds [PDF]

Veterinary World, 2019
Aim: This study aimed to investigate the impact of rabbit serum on skin wound healing with the help of histological examination. Materials and Methods: A total of ten indigenous rabbits were used in this study. The animals were divided into two groups:
Abeer Ahmed Majeed, Dhyaa Ab. Abood
doaj   +1 more source

Changes in the activity of lysosomal cysteine proteases of plasma mononuclear and polymorphonuclear blood leukocytes in Alzheimer’s disease

Бюллетень сибирской медицины, 2020
Aim. To study the level of activity of lysosomal cysteine proteases (cathepsins H, B, L) in blood plasma and fractionated leukocytes (polymorphonuclear and mononuclear) in patients with Alzheimer’s disease in comparison with similar indicators in persons
M. G. Sorokina, M. A. Fomina, D. S. Petrov, N. V. Korotkova   +3 more
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Cytokine Profile in Human Peripheral Blood Mononuclear Leukocytes Exposed to Immunoadjuvant and Adjuvant-Free Vaccines Against Influenza

Frontiers in Immunology, 2020
Background: In the last decade, adjuvant-containing vaccines, exerting different effects on the immune system, including the production of cytokines, which are one of the most important regulatory systems of the body, are introduced into practice ...
Mikhail Petrovich Kostinov, Mikhail Petrovich Kostinov, Nelli Kimovna Akhmatova, Ekaterina Alexandrovna Khromova, Aristitsa Mikhailovna Kostinova   +4 more
doaj   +1 more source

The Effect of Intracellular Tacrolimus Exposure on Calcineurin Inhibition in Immediate- and Extended-Release Tacrolimus Formulations

Pharmaceutics, 2023
Despite intensive monitoring of whole blood tacrolimus concentrations, acute rejection after kidney transplantation occurs during tacrolimus therapy.
Pere Fontova, Lisanne N. van Merendonk, Anna Vidal-Alabró, Raül Rigo-Bonnin, Gema Cerezo, Stefaan van Oevelen, Oriol Bestard, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Joan Torras, Josep M. Cruzado, Josep M. Grinyó, Helena Colom, Nuria Lloberas   +15 more
doaj   +1 more source