Results 281 to 290 of about 2,424,061 (363)

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Aging and Peripheral Nerve Injuries: Impaired Repair, Inflammaging Impact, and Regeneration Resistance. [PDF]

Biomedicines
Gu X, Lin M, Xia Y, Cheng X, Pan H, Cai M, Jiang M, Yao D.   +7 more
europepmc   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

The neuroimmune microenvironment of peripheral nerve injury: mechanisms, pathophysiology, and therapeutic implications. [PDF]

Front Surg
Warner WS, Rose M, Yeoh S, Muhlestein WE, Noroozi Gilandehi S, Mahan MA.   +5 more
europepmc   +1 more source

A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun, Jing Zhang, Chenqing Liu, Jing Lou, Sihui Wang, Xiangtian Ji, Xiaofang Zhao, Shirui Xu, Jingyu Feng, Bin Liu, Chao Chang, Qinggang Ge, Jun Yang   +12 more
wiley   +1 more source

Peripheral nerve sheath tumors-on-a-chip: Next-generation platforms for mechanistic and therapeutic studies. [PDF]

Mater Today Adv
Delaney WH, Faulkner SA, Lam WA, Boulis NM, Qiu Y, Lei K.   +5 more
europepmc   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Editorial: 7th international symposium on peripheral nerve regeneration: peripheral nerve regeneration - advances and new directions. [PDF]

Front Cell Dev Biol
Alvites R, García ÓD.
europepmc   +1 more source

All-in-one nerve guidance: transplanting a gradient scaffold with immobilized Schwann cells for peripheral nerve regeneration. [PDF]

Mater Today Bio
Zhu S, Cui R, Qiu S, Zhang X, Ma J, Duan W, Li P, Quan D, Yang Z, Zhang S, Rao Z, Bai Y.   +11 more
europepmc   +1 more source

Radiomics Applied to the Diagnosis of Peripheral Nerve Disorders: A Systematic Review and Meta-Analysis of the Existing Literature. [PDF]

J Clin Med
Armato V, Susi ME, Picasso R, Macciò M, Pistoia F, Zaottini F, Martinoli C, Ferrero G, Bignotti B, Tagliafico AS.   +9 more
europepmc   +1 more source