Results 31 to 40 of about 19,735,029 (303)

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Peripheral nervous system involvement in lymphomas

, 2018
The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections ...
Cavallaro, T., Visentin, Andrea, Visentin, A., Campagnolo, Marta, Campagnolo, M., Manara, R., Marta Campagnolo, Briani, C., Salvalaggio, Alessandro, Chiara Briani, Ferrari, Sergio, Salvalaggio, A., Manara, Renzo, Alessandro Salvalaggio, Renzo Manara, Roberto Gasparotti, Briani, Chiara, Andrea Visentin, Francesco Piazza, Gasparotti, R., Ferrari, S., Tiziana Cavallaro, Cavallaro, Tiziana, Sergio Ferrari, Gasparotti, Roberto, Piazza, Francesco, Piazza, F.   +26 more
core   +1 more source

Results of the survey of the physicians opinion on medical rehabilitation organization of children in Russian federation regions

Журнал инфектологии, 2018
The purpose of the study: the study of expert opinions of specialists from different regions of the Russian Federation on the  organization of rehabilitation of children with diseases of the central  and/or peripheral nervous system, including pediatric ...
I. G. Samojlova
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Toward European harmonization of national myasthenia gravis registries: modified Delphi procedure-based expert consensus on collectable data

Orphanet Journal of Rare Diseases
Background Myasthenia gravis (MG) is a rare autoimmune disorder. Several new treatment concepts have emerged in recent years, but access to these treatments varies due to differing national reimbursement regulations, leading to disparities across Europe.
Abderhmane Slioui, Giulia Tammam, Fiammetta Vanoli, Adela Della Marina, Stanislav Vohanka, Nils Erik Gilhus, Isabella Moroni, Maria Isabel Leite, Fredrik Piehl, Carlo Antozzi, Jonathan Pini, Frauke Stascheit, Shahram Attarian, Ernestina Santos, Jan Verschuuren, Lou Canonge, Jeremy Garcia, Caroline Perriard, Elena Cortés-Vicente, Renato Mantegazza, Andreas Meisel, Sabrina Sacconi   +21 more
doaj   +1 more source

Impairment of the Peripheral Nervous System in Creutzfeldt-Jakob Disease [PDF]

Archives of Neurology, 2002
The clinical manifestations of Creutzfeldt-Jakob disease (CJD) primarily reflect involvement of the central nervous system. The coexistence of CJD with peripheral nervous system involvement has also been reported.To analyze peripheral neuron electrophysiologic changes and to compare these data with neuropathologic features of spinal motor neurons in ...
Maria, Niewiadomska, Jerzy, Kulczycki, Danuta, Wochnik-Dyjas, Grazyna M, Szpak, Maria, Rakowicz, Wanda, Łojkowska, Krystyna, Niedzielska, Ewa, Inglot, Malgorzata, Wieclawska, Czeslaw, Glazowski, Eugenia, Tarnowska-Dziduszko   +10 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Psychosocial resources and psychopathology among persons with neuromuscular disorders during the COVID-19 pandemic

BMC Psychology
Background The COVID-19 pandemic substantially affected the lives of persons with inherited neuromuscular disorders (INMD), causing disruption in clinical and support services.
Silvia Sanzo’, Federica Tizzoni, Stefano C. Previtali, Angela Berardinelli, Maria Nobile, Massimo Molteni, Martina Manzoni, Arianna Tarabelloni, Annamaria Russo, Antonella Delle Fave, Maria Grazia D’Angelo   +10 more
doaj   +1 more source