Results 121 to 130 of about 1,609,082 (287)

EXPRESS: Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI) [PDF]

, 2019
Pulmonary hypertension is highly heterogeneous and despite treatment advances it remains a life shortening condition. There have been significant advances in imaging technologies, but despite evidence of their potential clinical utility practice remains
Swift, Andrew J., van Beek, Edwin, Olschewski, H., Horst Olschewski, Kiely, D., Screaton, Nicholas J, Michal Schafer, Rahaghi, F., David G. Kiely, Rebecca Vandepool, Tawhai, M., Mazurek, Jeremy, Rahaghi, Farbod N., Vogel-Claussen, J., Swift, Andrew, Levin, David L., Tawhai, Merryn, Ivy, David D, Andrew J. Swift, Swift, A., Van Beek, Edwin Jr, Angela Lungu, Schiebler, Mark, Schiebler, M., Bwika, J., Jone, P.-N., Dunbar Ivy, Kawut, S.M., Peacock, Andrew J., Stephen J. Wort, Kiely, David, Levin, D., Wild, J., David L. Levin, Puri, G D, Wild, Jim M, Olschewski, Horst, Schafer, M., Vanderpool, R.R., Vonk-Noordegraaf, Anton, G.D. Puri, Wort, John, Peacock, A., Hassoun, Paul M, Hassoun, Paul, Hassoun, Paul M., Jone, Pei-Ni, Lungu, Angela, Vanderpool, Rebecca R, Moledina, S., Bwika, Jumaa, Schiebler, Mark L, Kiely, David G., Shahin Moledina, Farbod N. Rahaghi, Jim Lordan, Levin, David, Jens Vogel‐Claussen, Kawut, Steven M, Rahaghi, Farbod N, Wort, J., Ivy, D.D., Wild, Jim, Pei‐Ni Jone, Kawut, Steven M., Andrew J. Peacock, Puri, Goverdhan Dutt, Mazurek, J., Jumaa Bwika, Lordan, Jim, Zhao, Lan, Tawhi, Merryn, Dunbar, Ivy, Van Beek, E.J., Mazurek, Jeremy A, Screaton, Nicholas, Vonk-Noordegraaf, A., Rahaghi, Farbod, Steven M. Kawut, Zhao, L., Anton Vonk‐Noordegraaf, Wort, Stephen J., Vandepool, Rebecca, Ivy, Dunbar, Wort, S John, Lordan, J., Wild, Jim M., Moledina, Shahin, van Beek, Edwin J. R., Schafer, Michal, Kiely, David G, Paul M. Hassoun, Jim M. Wild, Swift, Andrew J, Puri, G. D., Vogel-Claussen, Jens, Jeremy A. Mazurek, Lungu, A., Puri, G.D., Screaton, N., Mazurek, Jeremy A., Nicholas Screaton, Merryn Tawhai, Hassoun, P., Mark Schiebler, Peacock, Andrew, Lan Zhao, Edwin J.R. van Beek   +107 more
core   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Accuracy of ultrasound-guided biopsy in comparison to computed tomography guided biopsy in the diagnosis of peripheral lung lesions

Egyptian Journal of Chest Disease and Tuberculosis
Background Although ultrasonography (US) may detect pulmonary pleural-based thoracic masses, it is still rarely used as a diagnostic biopsing tool for peripheral pulmonary lesions, which are found at the subsegmental bronchi and are usually not detected ...
Abdel Rahman M. Abdallah, Shaaban M. Ramadan, Ahmed S. Abdel Basset, Osama A. Abdelaal, Laila A. Al-Sharawy   +4 more
doaj   +1 more source

[Advances of Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2020
The incidence of peripheral pulmonary lesions (PPLs) is growing following the adoption of lung cancer screening by low-dose chest CT. The diagnosis and treatment of pulmonary nodules is one of the most difficult problems. Based on the electromagnetic positioning technology, the electromagnetic navigation bronchoscope is guided to the pulmonary nodules ...
Qiuming CHEN, Zhou AN, Jun CHENG, Wang LV, Jian HU   +4 more
openaire   +2 more sources

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source