Results 81 to 90 of about 1,596,501 (294)

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Clinical and morphological determinants of minimally-invasive electrical impedance spectroscopy measurements in pulmonary nodules: an exploratory correlation pilot study

Scientific Reports
Accurate diagnosis of peripheral pulmonary nodules remains challenging. Electrical impedance spectroscopy (EIS) may provide a radiation-free approach for pre-biopsy tissue characterization during bronchoscopy.
Albert Rafecas-Codern, Georgina Company-Se, Anna Farrés-Castany, Virginia Pajares, Ramon Bragós, Lexa Nescolarde   +5 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Application of Electromagnetic Navigation Bronchoscopic Biopsy Combined with 
Massage Staining in Diagnosis and Treatment of Peripheral Pulmonary Lesion

Chinese Journal of Lung Cancer, 2019
Background and objective Electromagnetic navigation bronchoscopy (ENB) has become the latest minimally invasive diagnostic and therapeutic technique due to its characteristics, e.g., non-invasion, accuracy, real-time positioning.
Kai QIAN, Yonggeng FENG, Ruwen WANG, Bo DENG, Qunyou TAN   +4 more
doaj   +1 more source

Isolated right pulmonary artery agenesis with aplasia of right upper lobe and with anomalous arterial supply from celiac axis, anomalous venous drainage

Medical Journal of Dr. D.Y. Patil University, 2015
Pulmonary artery agenesis is the complete absence of the right or left pulmonary artery. This lesion is commonly associated with other cardiac anomalies and is usually diagnosed incidentally. Unilateral absence of pulmonary artery with lung hypoplasia is
Tushar Madhav Kalekar, Vilas M Kulkarni, Tejasvi Thamatam   +2 more
doaj   +1 more source

Pulmonary Mycobacterium shinjukuense infection with cavitary lesion

Key message We report a rare case of pulmonary Mycobacterium shinjukuense infection with cavitary lesion.
Yuriko Sueda, Akira Yamasaki, Hiromitsu Sakai, Hirokazu Tokuyasu   +3 more
core   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

VATS intraoperative tattooing to facilitate solitary pulmonary nodule resection

Journal of Cardiothoracic Surgery, 2008
Introduction Video-assisted thoracic surgery (VATS) has become routine and widely accepted for the removal of solitary pulmonary nodules of unknown etiology.
Boutros Cherif, Willekes Lourens, Goldfarb Michael A   +2 more
doaj   +1 more source