Results 91 to 100 of about 1,596,501 (294)

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

A novel diagnostic approach for Pneumocystis jirovecii pneumonia using fine-needle aspiration, electromagnetic navigational bronchoscopy and rapid on-site evaluation

Annals of Thoracic Medicine, 2019
Cavitary lung lesions are common in patients with human immunodeficiency virus infections. Both atypical infections and thoracic malignancies can manifest as a cavitary pulmonary lesion.
Farnaz Houshmand, Fatima Zahra Aly, Mark Rollin Bowling   +2 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Diagnostic utility of transthoracic Doppler ultrasound in the assessment of peripheral pulmonary lesions

Egyptian Journal of Chest Disease and Tuberculosis
Background Transthoracic ultrasound is a safe, radiation-free, and cheap complementary radiological modality that helps in the detection of peripheral pulmonary nodules, masses, or consolidations adherent to the parietal pleura. As a complementary method,
Rania M. Ali, Amina A. El-Maksoud, Amany R. Elsaid, Mohammed A. Elhawary, Marwa O. Elmaria   +4 more
doaj   +1 more source

Mini-loop ligation of a bleeding duodenal Dieulafoy's lesion [PDF]

, 2013
Two percent of gastrointestinal hemorrhages are caused by Dieulafoy's lesions, which are located in duodenum in only 15% of cases. There are no recommendations regarding the prime endoscopic treatment technique for this condition.
Ljubičić, Neven, Gomerčić Palčić, Marija   +1 more
core   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Predictors of Diagnostic Yield in Shape-Sensing Robotic-Assisted Bronchoscopy (ssRAB): A Retrospective Single-Center Study

Diagnostics
Background/Objectives: Robotic-assisted bronchoscopy has emerged as an advanced technique for the evaluation of peripheral pulmonary lesions, offering improved navigation and targeting accuracy.
Hruy Menghesha, Jan Arensmeyer, Philipp Feodorovici, Mark Coburn, Dirk Skowasch, Tatjana Dell, Julian Luetkens, Joachim Schmidt, Donatas Zalepugas   +8 more
doaj   +1 more source

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

Accuracy of ultrasound-guided biopsy in comparison to computed tomography guided biopsy in the diagnosis of peripheral lung lesions

Egyptian Journal of Chest Disease and Tuberculosis
Background Although ultrasonography (US) may detect pulmonary pleural-based thoracic masses, it is still rarely used as a diagnostic biopsing tool for peripheral pulmonary lesions, which are found at the subsegmental bronchi and are usually not detected ...
Abdel Rahman M. Abdallah, Shaaban M. Ramadan, Ahmed S. Abdel Basset, Osama A. Abdelaal, Laila A. Al-Sharawy   +4 more
doaj   +1 more source

Evaluation of the contribution of fine-needle non-aspiration cytology to diagnosis in cases with pulmonary malignant lesions

, 2021
BACKGROUND/AIM: Fine-needle non-aspiration cytology (FNNAC) is an easy-to-apply, minimally invasive diagnostic method that contributes to the diagnosis and staging of lung cancer.
DÜNDAR, Emine, METİNTAŞ, Muzaffer, Güntülü, AK, Ak, GÜNTÜLÜ, METİNTAŞ, Selma, YILMAZ, Şenay   +5 more
core   +1 more source