Results 111 to 120 of about 1,660,629 (240)

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Application of hand-drawn bronchial navigation and rapid on-site evaluation combined with endobronchial ultrasound for the diagnosis of peripheral lung lesions

Journal of International Medical Research
Objective To investigate the clinical value of radial endobronchial ultrasound (rEBUS) combined with rapid on-site evaluation (ROSE) under hand-drawn bronchial navigation (HBN) planning for the diagnosis of peripheral pulmonary lesions.
Maofei Fan, Renyuan Zhao, Qian Zhu, Menglin Zhang, Qingqing Zhou, Xiwei Hu   +5 more
doaj   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Electromagnetic navigation bronchoscopy for the diagnosis and treatment of respiratory disease: current and future perspective

Zhongguo aizheng zazhi, 2015
Bronchoscopy is a minimally invasive method for obtaining peripheral pulmonary lesions (PPL). Traditional bronchoscopy-guided transbronchial lung biopsy (TBLB) is performed under X-ray guidance, and diagnostic rate is relatively low.
孙加源, 韩宝惠, 陈海泉
doaj  

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Accuracy of ultrasound-guided biopsy in comparison to computed tomography guided biopsy in the diagnosis of peripheral lung lesions

Egyptian Journal of Chest Disease and Tuberculosis
Background Although ultrasonography (US) may detect pulmonary pleural-based thoracic masses, it is still rarely used as a diagnostic biopsing tool for peripheral pulmonary lesions, which are found at the subsegmental bronchi and are usually not detected ...
Abdel Rahman M. Abdallah, Shaaban M. Ramadan, Ahmed S. Abdel Basset, Osama A. Abdelaal, Laila A. Al-Sharawy   +4 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Diagnostic utility of transthoracic Doppler ultrasound in the assessment of peripheral pulmonary lesions

Egyptian Journal of Chest Disease and Tuberculosis
Background Transthoracic ultrasound is a safe, radiation-free, and cheap complementary radiological modality that helps in the detection of peripheral pulmonary nodules, masses, or consolidations adherent to the parietal pleura. As a complementary method,
Rania M. Ali, Amina A. El-Maksoud, Amany R. Elsaid, Mohammed A. Elhawary, Marwa O. Elmaria   +4 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Yield of Navigational Ultrathin Bronchoscopy with Fluoroscopy in Diagnosis of Pulmonary Nodules [PDF]

Al-Azhar International Medical Journal
Background: Although many of the tiny lesions found on simple chest radiography are benign, CT finds more PPLs than radiography. Thus, it is essential to be able to differentiate benign lesions from lung cancer using a safer and more reliable technique ...
doaj   +1 more source