Results 81 to 90 of about 1,913,743 (283)

Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia

BMC Infectious Diseases, 2020
Background Diabetes mellitus (DM) is thought to affect tuberculosis (TB) clinical presentation and treatment response. Whether DM impacts radiological manifestations of pulmonary TB is still not clear.
Nadia Nilda Barreda, Maria B. Arriaga, Juan Gonzalo Aliaga, Kattya Lopez, Oswaldo Martin Sanabria, Thomas A. Carmo, José F. Fróes Neto, Leonid Lecca, Bruno B. Andrade, Roger I. Calderon   +9 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

The Value of Combined Radial Endobronchial Ultrasound-Guided Transbronchial Lung Biopsy and Metagenomic Next-Generation Sequencing for Peripheral Pulmonary Infectious Lesions

Canadian Respiratory Journal, 2020
Background. Metagenomic next-generation sequencing (mNGS) is a new technology that allows for unbiased detection of pathogens. However, there are few reports on mNGS of lung biopsy tissues for pulmonary infection diagnosis.
Guangsheng Li, Jie Huang, Yuechuan Li, Jing Feng   +3 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

The diagnostic value of ultrasound-guided percutaneous transthoracic core-needle biopsy versus computed tomography-guided biopsy in peripheral intrathoracic lesions

The Egyptian Journal of Bronchology, 2016
Introduction Transthoracic ultrasound has become an important diagnostic tool in peripheral intrathoracic lesions. Transthoracic needle biopsy is a relatively safe and easy procedure under real-time ultrasound (US) guidance, and may provide adequate ...
Wafaa S. El-Shimy, Fawzy A. El-Emery, Ayman H. Abd El-Zaher, Amr M. El-Badry, Dalia E. El-Sharawy   +4 more
doaj   +1 more source

Evaluation of the contribution of fine-needle non-aspiration cytology to diagnosis in cases with pulmonary malignant lesions

, 2021
BACKGROUND/AIM: Fine-needle non-aspiration cytology (FNNAC) is an easy-to-apply, minimally invasive diagnostic method that contributes to the diagnosis and staging of lung cancer.
DÜNDAR, Emine, METİNTAŞ, Muzaffer, Güntülü, AK, Ak, GÜNTÜLÜ, METİNTAŞ, Selma, YILMAZ, Şenay   +5 more
core   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Differentiating lung neuroendocrine neoplasms from tumor-like infection using CT in patients with ectopic ACTH syndrome

Insights into Imaging
Objectives Pulmonary neuroendocrine neoplasms (NENs) are the most frequent cause of ectopic adrenocorticotropic hormone syndrome (EAS); lung infection is common in EAS. An imaging finding of infection in EAS patients can mimic NENs.
Lan Song, Hui Miao, Zhenchen Zhu, Huijuan Zhu, Jinhua Wang, Xiaoping Xing, Zhaohui Zhu, Yuanyuan Jiang, Ruie Feng, Yu Xiao, Lian Duan, Xin Sui, Qingxing Liu, Linjie Wang, Shi Chen, Wei Song, Zhengyu Jin, Lin Lu   +17 more
doaj   +1 more source

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

Endobronchial Ultrasound-Guided Transbronchial Biopsy of Peripheral Pulmonary Lesions: How Many Specimens Are Necessary?

, 2014
Background: Although endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) has been shown to increase the diagnostic yield over conventional bronchoscopic techniques, an important issue regarding the optimal number of biopsy specimens ...
Huang, Chun-Ta;Tsai, Yi-Ju;Liao, Wei-Yu;Wu, Pei-Chen;Ho, Chao-Chi;Yu, Chong-Jen;Yang, Pan-Chyr, 楊泮池 ;廖唯昱 ;余忠仁 ;何肇基 ;黃俊達   +1 more
core   +1 more source