Results 211 to 220 of about 16,366 (275)

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 9, Page 1824-1844, May 2026.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam   +12 more
wiley   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

open access: yesCell Proliferation, Volume 59, Issue 5, May 2026.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang   +12 more
wiley   +1 more source

Clinical Trials in Central Venous Access Devices: An Evidence and Gap Map

open access: yesJournal of Advanced Nursing, Volume 82, Issue 5, Page 4524-4537, May 2026.
ABSTRACT Aims To systematically map the landscape of central venous access device research from 2014 to 2024, identifying critical gaps in evidence that may impact nursing practice and patient outcomes across the full device lifecycle from selection through to removal.
Mari Takashima   +14 more
wiley   +1 more source

Success Rate of Adrenal Venous Sampling and the Location of Right Adrenal Vein Orifice: A Retrospective Study

open access: yesThe Journal of Clinical Hypertension, Volume 28, Issue 5, May 2026.
ABSTRACT Adrenal venous sampling (AVS) is the gold standard for identifying aldosterone‐producing adenoma and bilateral adrenal hyperplasia. This study reports the success rate of AVS and the distribution characteristics of the right adrenal vein orifice (RAVO). The data of 166 patients with primary hyperaldosteronism who underwent AVS in Fuwai Central
Min‐Fu Bai   +6 more
wiley   +1 more source

Influence of low‐dose dopamine on exercise in fibrosing interstitial lung disease

open access: yesExperimental Physiology, Volume 111, Issue 5, Page 2682-2695, 1 May 2026.
ABSTRACT Fibrotic interstitial lung disease (FILD) is associated with dyspnoea and exercise intolerance. In other cardiorespiratory conditions, heightened carotid body (CB) chemoreflex sensitivity is associated with reduced exercise capacity. We tested the hypothesis that CB chemoreflex inhibition would improve exercise endurance time (EET) and reduce ...
Charlotte Chen   +6 more
wiley   +1 more source

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