Perirhinal cortex lesions impair tests of object recognition memory but spare novelty detection [PDF]
This article is protected by copyright. All rights reserved. Acknowledgements This work was supported by the Wellcome Trust (WT103722/Z/14/Z). The authors wish to thank L. Kinnavane and J. M. Pearce for their contributions to the manuscript.
Aggleton, John P +3 more
core +3 more sources
Dynamic Updating of Cognitive Maps via Traces of Experience in the Subiculum
ABSTRACT In the classical view of hippocampal function, the subiculum is assigned the role of the output layer. In spatial paradigms, some subiculum neurons manifest as so‐called boundary vector cells (BVCs), firing in response to boundaries at specific allocentric directions and distances.
Fei Wang, Andrej Bicanski
wiley +1 more source
Advanced Age Dissociates Dual Functions of the Perirhinal Cortex [PDF]
The perirhinal cortex (PRC) is proposed to both represent high-order sensory information and maintain those representations across delays. These cognitive processes are required for recognition memory, which declines during normal aging. Whether or not advanced age affects the ability of PRC principal cells to support these dual roles, however, is not ...
Sara N, Burke +5 more
openaire +2 more sources
Short-term memory trace in rapidly adapting synapses of inferior temporal cortex. [PDF]
Visual short-term memory tasks depend upon both the inferior temporal cortex (ITC) and the prefrontal cortex (PFC). Activity in some neurons persists after the first (sample) stimulus is shown. This delay-period activity has been proposed as an important
Yasuko Sugase-Miyamoto +4 more
doaj +1 more source
Microstructural Alterations in Hippocampal Subfields Mediate Age-Related Memory Decline in Humans. [PDF]
Aging, even in the absence of clear pathology of dementia, is associated with cognitive decline. Neuroimaging, especially diffusion-weighted imaging, has been highly valuable in understanding some of these changes in live humans, non-invasively ...
Radhakrishnan, Hamsanandini +2 more
core
Electrophysiological Signatures of Spatial Boundaries in the Human Subiculum. [PDF]
Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of ...
Aronson, Joshua P. +16 more
core +2 more sources
Spatial Organization of Morpho‐Electric Subtypes of Pyramidal Neuron in the Subiculum
ABSTRACT The subiculum is a main output structure of the hippocampus, transmitting information from the CA1 to the entorhinal cortex in a spatially structured manner. Prior studies revealed a high electrophysiological and molecular heterogeneity of subicular pyramidal neurons (PYNs) with evidence for further spatial subdivisions of the subiculum.
Alix Guinet +3 more
wiley +1 more source
Stimulus-Related Activity during Conditional Associations in Monkey Perirhinal Cortex Neurons Depends on Upcoming Reward Outcome [PDF]
journal ...
Matsumoto Narihisa +4 more
core +1 more source
Upstream CB1R Regulation of β‐Adrenergic Memory Consolidation
ABSTRACT Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β‐adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus.
Janine I. Rossato +9 more
wiley +1 more source
We investigated the potential of 4-AP (50–100 μM) to induce seizure-like events (SLEs) in combined entorhinal cortex–hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus.
Robert K. Zahn +5 more
doaj +1 more source

