We summarize recent findings on the cell biological aspects of peritoneal metastasis and potential therapeutic target molecules. We focus on the molecular mechanisms underlying cluster/spheroid formation in multiclonal peritoneal metastasis and cancer–stroma interactions within the peritoneal tumor microenvironment. ABSTRACT Peritoneal metastasis, also
Hideki Yamaguchi, Makoto Miyazaki
wiley +1 more source
Safe abortion – Still a neglected scenario: A study of septic abortions in a tertiary hospital of Rural India [PDF]
Background and Aims: In spite abortion has been legalized in India over three decades, unsafe abortion continues to be a significant contributor of maternal mortality and morbidity.
Bhattacharya, S+3 more
core +1 more source
Bosutinib mitigates inflammation in experimental sepsis
Abstract Background Sepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical
C. M. C. Cunha+14 more
wiley +1 more source
Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib. [PDF]
Signaling via the B cell receptor (BCR) plays an important role in the pathogenesis and progression of chronic lymphocytic leukemia (CLL). This is underscored by the clinical effectiveness of ibrutinib, an inhibitor of Bruton's tyrosine kinase (BTK) that
Chen, L+9 more
core
Peritoneal repairing cells: A type of bone marrow derived progenitor cells involved in mesothelial regeneration [PDF]
The peritoneal mesothelium exhibits a high regenerative ability. Peritoneal regeneration is concomitant with the appearance, in the coelomic cavity, of a free-floating population of cells whose origin and functions are still under discussion.
Bera, T. K.+7 more
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Summary Background Reaching a specific diagnosis in horses with chronic or recurrent abdominal pain may be challenging and elusive. Objectives The aim of this study was to report indications, findings and outcomes of equine exploratory laparoscopy in a case series to support its diagnostic value and identify potential limitations.
Tanja Pudert+2 more
wiley +1 more source
A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer [PDF]
Background There is lack of uniformity in the utilization of peritoneal cytology in gastric cancer management. the identification of intraperitoneal free cancer cells (IFCCs) is believed to confer poor prognosis. However, while some of these patients are
Cardoso, Roberta+7 more
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Fungal endometritis associated with embryonic loss in a maiden mare
Summary Fungal endometritis and placentitis have been reported as a rare but important cause of infertility in the mare. There are no reported clinical cases of fungal endometritis causing embryonic loss in the mare. This case report aims to highlight the potential of fungal endometritis as an aetiological agent in embryonic loss in the mare; an ...
A. Gunn+3 more
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Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury. [PDF]
The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents ...
Altshuler, Angelina E+5 more
core +2 more sources
Diagnostic peritoneal lavage—an obituary
Replaced by ...
Jan O. Jansen, J. R. C. Logie
openaire +3 more sources