Results 51 to 60 of about 10,452 (228)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Case of Peritoneal Malignant Mesothelioma in a 60-year-old Lady Presenting Clinically With Huge Abdominopelvic Mass: A Diagnostic Challenge [PDF]

Journal of Clinical and Diagnostic Research
Peritoneal malignant mesothelioma is a rare tumour that poses diagnostic challenges due to vague clinical symptoms, a variable histologic picture and being a common site for metastasis from GI organ, ovary, kidney and several other organs. We presented a
Usha Sarma, Rituparna Das, Mayurpankhi Saikia   +2 more
doaj   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Peritoneal mesothelioma with invasion of the urinary bladder 20 years post radiation therapy for colon adenocarcinoma [PDF]

, 2021
Nicole Ong Mingjing, Abdul Samad Asamu, Keith Pace, Simon Bugeja   +3 more
openalex   +1 more source

Mesotelioma peritoneal maligno.

Acta Médica Portuguesa, 2011
Malignant peritoneal mesothelioma is a rare tumor arising from the mesothelial cells of this serosal membrane. The authors report a case of a female patient referred to our hospital for ascites of unknown etiology.
Cláudia Cardoso, Elia Gamito, Carlos Quintana, Ana Paula Oliveira   +3 more
doaj   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

Malignant mesothelioma in rare sites: two case reports

Frontiers in Oncology
Mesothelioma is a rare tumor originating from mesothelial cells in the pleura or other sites. Malignant pleural mesothelioma (MPM) is the most common aggressive type of mesothelioma (accounting for 81%) and carries a poor prognosis (median OS: 1 year ...
Qiguang Du, Jialu Guo, Zi Zhu, Yutong Zhang, He Cui, Zhongkai Xu, Rang Yang, Wenlong Liang   +7 more
doaj   +1 more source

Effusion‐Dominant Pulmonary Sarcomatoid Carcinoma Without a Primary Mass: A Case Report

Respirology Case Reports, Volume 14, Issue 1, January 2026.
We describe a patient with high‐grade sarcomatoid carcinoma presenting as malignant pleural effusion without a primary mass. This case highlights the diagnostic challenges, aggressive clinical course, and importance of early biopsy. We also review the limited literature describing similar presentations.
Sze Kye Teoh, Yen Shen Wong, Yiet Fai Ng, Yu Wei Cheah, Suhashini Ganapaty, Saiful Safuan Md Sani   +5 more
wiley   +1 more source

Malignant peritoneal mesothelioma in a woman with bilateral ovarian serous borderline tumour: Potential interactions between the two diseases

Gynecologic Oncology Reports, 2018
We report a case of a 59-year-old woman with peritoneal malignant mesothelioma and no previous exposure to asbestos with a diagnosis of bilateral ovarian serous borderline tumour with peritoneal implants one year before.
Lorena Losi, Laura Botticelli, Gianluca Taccagni, Ernesto Longinotti, Cesare Lancellotti, Letizia Scurani, Gian Franco Zannoni   +6 more
doaj   +1 more source

A Case of Peritoneal Sarcomatoid Mesothelioma with Absence of Occupationl Exposure to Asbestos [PDF]

Kosin Medical Journal, 2019
Sarcomatoid mesothelioma is not very common, mesothelioma is directly attributable to occupational asbestos exposure, with 90% of cases showing a history of exposure. A 66-year-old male was admitted with an abdominal pain that persisted for 3 weeks.
Seung Hoon Yoo, Hee Man Kim, Jea Kun Park, Mi Sung Kim, Sang Yeop Yi   +4 more
doaj   +1 more source