Results 51 to 60 of about 17,743 (275)

Dramatic tumour response to pemetrexed single-agent in an elderly patient with malignant peritoneal mesothelioma: a case report

BMC Cancer, 2006
Background To date, there is no standard treatment for unresectable malignant peritoneal mesothelioma; either best supportive care or systemic chemotherapy with palliative intent are accepted options.
Di Terlizzi Silvia, Aita Marianna, Follador Alessandro, Puglisi Fabio, Fasola Gianpiero, Belvedere Ornella   +5 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Epidemiology and clinical characteristics of mesothelioma in the Chinese population: a multicenter study

Therapeutic Advances in Medical Oncology
Background: Mesothelioma is a rare and highly aggressive tumor that causes severe damage. However, there is a lack of systematic reports on the incidence and clinical characteristics of mesothelioma in the Chinese population.
Shengjie Yang, Yue Hao, Ke Wang, Haipeng Xu, Long Huang, Ling Xu, Rui Meng, Bihui Li, Jianhui Huang, Youcai Zhu, Xuefei Shi, Dong Wang, Ziyan Yang, Zhenying Guo, Jingxun Wu, Wenfeng Li, Jianfei Fu, Yinghua Ji, Zongyang Yu, Miao Li, Huijing Feng, Lin Wang, Qing Ji, Wenjun Tang, Zhengbo Song, Chunwei Xu, Qian Wang   +26 more
doaj   +1 more source

Anti-Tumor Effects of TRAIL-Expressing Mesenchymal Stromal Cells in a Mouse Xenograft Model of Human Mesothelioma [PDF]

, 2015
Malignant mesothelioma (MM) remains a highly deadly malignancy with poor treatment option. The MM cells further promote a highly inflammatory microenvironment which contributes to tumor initiation, development, severity, and propagation. We reasoned that
Janes, SM, Sage, E
core  

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Biochemical and haemostatic variables associated with metastasis in dogs with carcinoma or sarcoma

Journal of Small Animal Practice, EarlyView.
Objectives Identify alterations in biochemical and haemostatic variables between tumour‐bearing dogs with and without metastasis that can be used to predict the presence of metastasis. Materials and Methods Thirty dogs with sarcoma and 29 with carcinoma were included in the analysis.
P. Pazzi, G. T. Fosgate, A. T. Kristensen, A. Goddard   +3 more
wiley   +1 more source

National Mesothelioma Virtual Bank: A standard based biospecimen and clinical data resource to enhance translational research [PDF]

, 2008
Background: Advances in translational research have led to the need for well characterized biospecimens for research. The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an ...
AA Patel, Althea M Schneider, Andrew K Pople, Anil V Parwani, E Eiseman, Federico A Valdivieso, Ghada Farhat, Harvey I Pass, ID Fleming, ISBER, John T Milnes, Jonathan Melamed, Linda Schmandt, Michael Feldman, Michael J Becich, Nancy B Whelan, Rajiv Dhir, Sambit K Mohanty, Sharon B Winters, SJ Qualman, Waqas Amin   +20 more
core   +4 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Switching off malignant mesothelioma : exploiting the hypoxic microenvironment [PDF]

, 2017
Malignant mesotheliomas are aggressive, asbestos-related cancers with poor patient prognosis, typically arising in the mesothelial surfaces of tissues in pleural and peritoneal cavity.
Bennewith, KL, Churg, A, Collins, CC, Mutti, L, Nabavi, N, Wang, Y   +5 more
core   +1 more source

Peritoneal mesothelioma with invasion of the urinary bladder 20 years post radiation therapy for colon adenocarcinoma [PDF]

, 2021
Nicole Ong Mingjing, Abdul Samad Asamu, Keith Pace, Simon Bugeja   +3 more
openalex   +1 more source