Results 111 to 120 of about 45,729 (318)

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Diagnostic Value of Carcinoembryonic Antigen in Ascites for Colorectal Cancer with Peritoneal Carcinomatosis

The Korean Journal of Gastroenterology, 2018
Background/Aims: Diagnostic tests for carcinoembryonic antigen (CEA) in ascites have been performed in various malignant cases, but there is only few data on the applicability of CEA for colorectal cancer (CRC) patients with peritoneal carcinomatosis. We
Sung Eun Song, Paul Choi, Jae Hyun Kim, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park   +7 more
doaj   +1 more source

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

Advanced Science, EarlyView.
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu, Zhangjin Shen, Shizhen Shen, Conghui Wang, Yuwan Liu, Xinyi Wei, Mengxia Zheng, Jiaxin Gu, Xiaojing Chen, Yi Sun, Junfen Xu, Yan Lu, Weiguo Lu   +12 more
wiley   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

Radiologic Manifestation of Intra-Abdominal Involvement of Systemic Amyloidosis Secondary to Renal Cell Carcionma

대한영상의학회지, 2018
Amyloidosis has a wide spectrum of manifestations in numerous abdominal organs. It can be categorized into primary or secondary disease according to the presence of accompanying conditions, such as rheumatoid arthritis, tuberculosis, or neoplasms ...
You Jin Lee, Ga Jin Han, Suk Kim, Nam Kyung Lee, Ho Jin Shin, Hong Koo Ha, Tae Un Kim   +6 more
doaj   +1 more source

Applying a random projection algorithm to optimize machine learning model for predicting peritoneal metastasis in gastric cancer patients using CT images [PDF]

arXiv, 2020
Background and Objective: Non-invasively predicting the risk of cancer metastasis before surgery plays an essential role in determining optimal treatment methods for cancer patients (including who can benefit from neoadjuvant chemotherapy). Although developing radiomics based machine learning (ML) models has attracted broad research interest for this ...
arxiv  

A proposal of Brazilian Society of Surgical Oncology for standardizing cytoreductive surgery plus hypertermic intraperitoneal chemotherapy procedures in Brazil: pseudomixoma peritonei, appendiceal tumors and malignant peritoneal mesothelioma

Revista do Colégio Brasileiro de Cirurgiões
Cytoreductive surgery plus hypertermic intraperitoneal chemotherapy has emerged as a major comprehensive treatment of peritoneal malignancies and is currently the standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome ...
Thales Paulo Batista, Bruno José Queiroz Sarmento, Janina Ferreira Loureiro, Andrea Petruzziello, Ademar Lopes, Cassio Cortez Santos, Cláudio de Almeida Quadros, Eduardo Hiroshi Akaishi, Eduardo Zanella Cordeiro, Felipe José Fernández Coimbra, Gustavo Andreazza Laporte, Leonaldson Santos Castro, Ranyell Matheus Spencer Sobreira Batista, Samuel Aguiar Júnior, Wilson Luiz Costa Júnior, Fábio Oliveira Ferreira   +15 more
doaj   +1 more source

Management of Low-Grade Appendiceal Mucinous Neoplasm with Extensive Peritoneal Spread Diagnosed during Pregnancy: Two Case Reports and Literature Review

Case Reports in Oncological Medicine, 2020
Background. Clinical decisions in patients with peritoneal dissemination of low-grade appendiceal mucinous neoplasms (LAMN) diagnosed during pregnancy are challenging.
Ekaterina Baron, Vadim Gushchin, Mary Caitlin King, Andrei Nikiforchin, Armando Sardi   +4 more
doaj   +1 more source

Role of Diffusion-Weighted MR Imaging in Characterization of Retro-Peritoneal Fibrosis and Differentiating it from Malignant Neoplasms [PDF]

, 2023
Mikel Sadek
openalex   +1 more source

The inhibitory effect of Yam polysaccharides on acrylamide‐induced programmed cell death in RAW 264.7 cells

Food Science &Nutrition, Volume 11, Issue 1, Page 443-457, January 2023., 2023
Acrylamide triggered macrophage cell apoptosis and autophagy and pyroptosis. ;P2X7 was of great significance in acrylamide‐induced cell death, but was mainly responsible for the regulation of autophagy and pyroptosis. Acrylamide stimulated oxidative stress via P2X7 in macrophage cells.
Jing Wang, Ying Han, Man Wang, He Li, Yujiao Sun, Xuefeng Chen   +5 more
wiley   +1 more source