Results 81 to 90 of about 591,059 (370)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Which patient is going to benefit from surgical cytoreduction with intraperitoneal chemotherapy (for manifest peritoneal metastases)?

Current Issues in Pharmacy and Medical Sciences, 2017
The gastric cancer with peritoneal metastases still represents a serious problem in the oncological surgery, whereas the peritoneal metastases arising from colorectal cancer can be successfully treated using a multimodal therapy concept consisting of ...
Blaj Sebastian, Piso Pompiliu
doaj   +1 more source

Society of Onco-Anaesthesia and Perioperative Care consensus guidelines for perioperative management of patients for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC)

Indian Journal of Anaesthesia, 2019
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for primary peritoneal malignancies or peritoneal spread of malignant neoplasm is being done at many centres worldwide.
Sohan Lal Solanki, Sudipta Mukherjee, Vandana Agarwal, Raghu S Thota, Kalpana Balakrishnan, Shagun Bhatia Shah, Neha Desai, Rakesh Garg, Reshma P Ambulkar, Nitin Madhukar Bhorkar, Viplab Patro, Snita Sinukumar, Meenakshi V Venketeswaran, Malini P Joshi, Rajesh Holalu Chikkalingegowda, Vijaya Gottumukkala, Pascal Owusu-Agyemang, Avanish P Saklani, Sanket Sharad Mehta, Ramakrishnan Ayloor Seshadri, John C Bell, Sushma Bhatnagar, Jigeeshu V Divatia   +22 more
doaj   +1 more source

Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report [PDF]

, 2013
Introduction: In this report, we present the case of a patient affected by appendiceal cystadenoma, a colorectal adenocarcinoma, and a concomitant bladder carcinoma, as well as the results of the molecular study of the most relevant mutational pathways ...
Colombino, Maria, Cossu, Antonio, Paliogiannis, Panagiotis, Palmieri, Giuseppe, Pulighe, Fabio, Scognamillo, Fabrizio, Trignano, Mario   +6 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Laparoscopic resection of gastric GISTs. Where do we stand now? A single-centered experience [PDF]

, 2019
Introduction. Gastrointestinal stromal tumors (GISTs) represent a rare type of gastrointestinal neoplasms. Resection with negative margins has been established as a mainstay treatment, but laparoscopic resections are still open to debate.
Alecu, Lucian, Nitipir, Cornelia, Slavu, Iulian, Stanculeanu, Dana L, Tulin, Adrian   +4 more
core   +2 more sources

Multifunctional Small Intestinal Submucosa Mesh for Scarless Abdominal Wall Defect Repair

Advanced Materials Interfaces, EarlyView.
a) Schematic illustration of the SIS/PCA/Mg mesh preparation. b) Schematic illustration of the repair of full‐thickness abdominal wall defects by multifunctional and degradable SIS/PCA/Mg mesh. ABSTRACT Decellularized small intestinal submucosa (SIS) mesh used for the treatment of abdominal wall defects often suffers from a high risk of recurrence due ...
Fuxin Tang, Zehui Hou, Haonan Huang, Xingxing Xie, Shuang Chen, Wenchang Gan, Ning Ma, Taicheng Zhou   +7 more
wiley   +1 more source

The enigma of struma ovarii [PDF]

, 2007
Since its first description in the early part of the twentieth century, struma ovarii has elicited considerable interest because of its many unique features; however, at present a number of aspects remain enigmatic.
Roth, Lawrence M., Talerman, Aleksander
core   +2 more sources

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative surgery for colon cancer [PDF]

, 2009
<b>Aim</b>: To comprehensively compare the prognostic value of tumour and patient-related factors in patients undergoing curative surgery for colon cancer.
Benson, Brown, Compton, Cooper, Crozier, Dukes, Forrest, Gabay, Gasser, Halazun, Hauser, Ishizuka, Kacevska, Kandemir, Kim, Kobayashi, Lee, Leitch, Lindmark, Maltoni, McMillan, McMillan, Mehrkhani, Michael, Moertel, Monreal, Morris, Petrelli, Ramsey, Roxburgh, Sasaki, Sharma, Smith, Taylor, Thynne, Vakkila, Vibert, Viganó, Walsh, Wanebo, Wang, Wolpin   +41 more
core   +1 more source