Results 281 to 290 of about 226,929 (358)

Imaging Diagnosis—Intestinal Leiomyositis in a 3‐Year‐Old Labrador Retriever

open access: yesVeterinary Radiology &Ultrasound, Volume 66, Issue 6, November 2025.
ABSTRACT A 3‐year‐old male neutered Labrador Retriever was originally presented to his primary care veterinarian for a 3–4‐week history of hyporexia, a 1‐week history of anorexia, and vomiting. There was moderate gastrointestinal (GI) distention with heterogeneous soft tissue luminal material within the small intestine in screening abdominal ...
Mercedes Cantu   +2 more
wiley   +1 more source

Asymmetric Synthesis and Biological Evaluation of 1,3‐ and 1,4‐Disubstituted Isoquinoline‐Containing Lipoxin A4 Analogues

open access: yesChemistry – A European Journal, Volume 31, Issue 56, October 8, 2025.
(1R)‐ and (1S)‐Epimers of novel isoquinoline‐derived SPMs were prepared, with a Pd‐catalyzed Heck reaction and a Ru(II)‐catalyzed asymmetric transfer hydrogenation as the key synthetic steps. Biological assessment demonstrated that several analogues significantly attenuate lipopolysaccharide‐induced NF‐κB activation and downstream pro‐inflammatory ...
Denise Moran   +4 more
wiley   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen   +9 more
wiley   +1 more source

A Charge‐Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
DNA gel bandage (DNAgb) is designed to precisely target the site of inflammation of IBD, by achieving dual specific localization of inflamed mucosa through electrostatic interactions and ApITGA4‐mediated affinity targeting. DNAgb effectively the activation of inflammatory pathways and reshapes the immune microenvironment.
Peifen Lu   +9 more
wiley   +1 more source

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