Results 41 to 50 of about 1,403,738 (310)
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
Toward mountains without permanent snow and ice
, 2017 The cryosphere in mountain regions is rapidly declining, a trend that is expected to accelerate over the next several decades due to anthropogenic climate change.
M. Huss +13 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
The Permanency of Paintings [PDF]
The Journal of Physical Chemistry, 1912 n ...
openaire +3 more sources
On the monotonicity of the permanent [PDF]
Proceedings of the American Mathematical Society, 1989 Let Ω n {\Omega _n} denote the set of all n × n n \times n doubly stochastic matrices and let J n = [ 1 / n ]
openaire +1 more source
Net Shape 3D Printed NdFeB Permanent Magnet [PDF]
, 2016 For two decades, NdFeB based magnets have been a critical component in a range of electrical devices engaged in energy production and conversion. The magnet shape and the internal microstructure of the selected NdFeB grade govern their efficiency and ...
J. Jaćimović +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
The Permanency of Continents [PDF]
Nature, 1884 As a small contribution to this theory, the Cornish beaches may furnish a quota. They are entirely composed of finely comminuted shells, with a small admixture of fragments of Bryozoa, spines of minute Echinoderms, and occasional mica flakes. Such sandy beaches occur in small bays, and if subjected to metamorphic action would form lenticular masses of ...
openaire +2 more sources