Results 51 to 60 of about 3,571,039 (253)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Permanent Agriculture: Precursor to Organic Farming [PDF]
, 2006 The concept of Permanent Agriculture predates Organic Agriculture by thirty years. Following a clash with the USDA over the theory of soil fertility, American soil scientist Franklin King wrote "Farmers of Forty Centuries or Permanent Agriculture in ...
Paull, John
core
Self-trapping of a binary Bose-Einstein condensate induced by interspecies interaction
, 2011 The problem of self-trapping of a Bose-Einstein condensate (BEC) and a binary BEC in an optical lattice (OL) and double well (DW) is studied using the mean-field Gross-Pitaevskii equation. For both DW and OL, permanent self-trapping occurs in a window of
Adhikari S K +9 more
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Comparitive study of the influence of harmonic voltage distortion on the efficiency of induction machines versus line start permanent magnet machines [PDF]
, 2012 Induction machines have nearly reached their maximal efficiency. In order to further increase the efficiency the use of permanent magnets in combination with the robust design of the induction machine is being extensively researched. These so-called line
Debruyne, Colin +3 more
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Permanent Homelessness in America? [PDF]
This paper seeks to determine the approximate number of homeless persons in the U.S., the rate of change in the number, and whether or not the problem is likely to be permanent or transitory.
Brian Hall, Richard B. Freeman
core
Permanent Legal Immigration to the United States: Policy Overview [PDF]
, 2014 Four major principles currently underlie U.S. policy on legal permanent immigration: the reunification of families, the admission of immigrants with needed skills, the protection of refugees, and the diversity of admissions by country of origin.
Kandel, William A
core +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source