Results 121 to 130 of about 10,994,822 (334)

Public health care staff during the COVID-19 pandemic: a comparison of job demands and work functioning between temporary and permanent staff

BMC Health Services Research
Background The COVID-19 pandemic posed an enormous challenge on the public health workforce, leading to the hiring of much temporary staff. Temporary staff may experience poorer working conditions compared to permanent staff.
Ylse van Dijk, Sarah I. M. Janus, Michiel R. de Boer, Sytse U. Zuidema, Sijmen A. Reijneveld, Corne A. M. Roelen   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Perceptions of permanent and contractual employees about a tobacco free workplace policy among four workplaces in Maharashtra, India

, 2018
Background Cigarettes and Other Tobacco Products Act, (COTPA) prohibits smoking in public places including indoor workplaces. Despite this, few workplaces in India have documented tobacco free workplace policies being implemented.
Leni Chaudhuri, Himanshu Gupte, Vaibhav Thawal, Gauri Mandal   +3 more
core   +1 more source

Flow at work in Italian journalists: differences between permanent and freelance journalists

, 2016
Flow is an inner experience produced by the participation in an activity in which people are immersed and enjoy it (Csikszentmihalyi, 1990). According to the Job Demands-Resources Model (Bakker and Demerouti, 2014), flow at work (FaW) occurs when job ...
Emanuel, Federica, Zito, Margherita, Colomba, Lara, Colombo, Lara   +3 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Earnings Dynamics and Inequality among Men across 14 EU Countries, 1994-2001: Evidence from ECHP [PDF]

This paper analyses the dynamic structure of individual earnings across 14 EU countries over the period 1994-2001 using ECHP. Understanding wage mobility and its link with the evolution of cross-sectional earnings inequality is important from a welfare ...
Sologon, Denisa Maria, O'Donoghue, Cathal   +1 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Do Flexible Employment Contracts Change Household Income Differences in Italy? [PDF]

This paper examines whether the growing use of non-permanent contracts may have inuenced the intra-family income differences in Italy over time. After the 1996, a number of reforms were imple- mented to reduce the levels of employment protection. Thus we
Fernanda Mazzotta, Lavinia Parisi, Carmen Aina   +2 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source