Results 21 to 30 of about 125,107 (259)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Multiscale Examination of Strain Effects in Nd-Fe-B Permanent Magnets [PDF]
Physical Review Applied, 2017 9 ...
Yi, Min +3 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Response of Different Types of Chocolate to Impact Loading – Direct Impact
Acta Technologica AgriculturaeThis study investigates the dynamic response of various chocolate types to direct impact at high strain rates, which has significant implications for practical applications such as production, packaging, and transportation. Five different chocolate types
Kumbár Vojtěch +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Investigation of tertiary Flow Behavior of bitumen stabilised materials with bitumen emulsion
Roads and Bridges, 2023 Cold recycling technology is gaining popularity as a sustainable way of rehabilitating existing asphalt pavements. Bitumen Stabilised Materials with bitumen emulsion (BSMs) are cold recycling mixtures (CRMs) that contain RAP, virgin aggregates, bitumen ...
Katarzyna Konieczna, Jan Król
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
BuildingsThe stable and safe operation of highway/railway lines is largely dependent on the dynamic behavior of subgrade fillings. Clay soils are widely used in subgrade construction and are compacted at different remolding water contents and compaction degrees ...
Shuai Qi +6 more
doaj +1 more source
EFFECT OF EXTERNAL FACTORS ON PERMENENT DEFORMATION BEHAVIOR OF LOCAL ASPHALT PAVEMENTS
Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ, 2018 Permanent deformation (rutting) is considered one of the most important factors that reduces pavement life in roads network and highways in Iraq. In this paper, a laboratory investigation has been conducted to evaluate the effect of external factors on ...
Abdulrada I.AI-kramee +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source