Results 51 to 60 of about 6,094,197 (290)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Permeability reduction effect and correction for low-permeability tight sandstone reservoirs under bound water saturation

Shiyou shiyan dizhi
Tight sandstone reservoirs with low-permeability under formation conditions are highly prone to bound water saturation, and the permeability of dried samples obtained by standard methods can not accurately reflect the reservoir properties.
Wenlong DENG, Liping LIU, Ping DAI, Li LI, Shunhua GAO, Xiaobing LIN   +5 more
doaj   +1 more source

Experimental Investigation of Polymer Adsorption-Induced Permeability Reduction in Low Permeability Reservoirs [PDF]

Journal of Petroleum & Environmental Biotechnology, 2014
The polymer retention during polymer flooding causes reduction in pore throat size which can be detrimental to oil recovery. Especially, in low permeability reservoir unlikely in high permeability system, EOR effect of polymer flooding would not excel comparing to water flooding because of the polymer adsorption onto grain surface.
openaire   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Experimental investigation of modified desulfurized gypsum-based concrete permeability performance [PDF]

Archives of Civil Engineering
To comprehend the permeability behavior of modified desulfurized gypsum-based concrete under varying stress conditions, this investigation conducted permeability assessments under both confining pressure and unloading circumstances.
Yong Luo, Shuai Ren, Diancai Xiao, Cong Gao, Linfeng Xu, Hao Wu   +5 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Experimental Investigation of Injection Pressure and Permeability Effect on CO₂ EOR for Light Oil Reservoirs

Gases
Gas injection is a well-established method for enhancing oil recovery by improving oil mobility, primarily through viscosity reduction. While its application in heavy oil reservoirs is extensively studied, the specific impact of carbon dioxide (CO2 ...
Khaled Enab
doaj   +1 more source

Experimental study on the effect of CO2 storage on the reservoir permeability in a CO2-based enhanced geothermal system

Geothermal Energy, 2023
A CO2-based Enhanced Geothermal System (CO2-EGS) has dual benefits of heat extraction and CO2 storage. Mineralization storage of CO2 may reduce reservoir permeability, thereby affecting heat extraction.
Pan Li, Yang Hao, Yu Wu, Ayal Wanniarachchi, Hongxue Zhang, Zhili Cui   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source