Results 61 to 70 of about 116,618 (260)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
A SAS/IML algorithm for an exact permutation test
GMS Medizinische Informatik, Biometrie und Epidemiologie, 2009 An algorithm written in SAS/IML is presented that can perform an exact permutation test for a two-sample comparison. All possible permutations are considered.
Neuhäuser, Markus +2 more
doaj
A Non-Parametric Test for a Two-Way Analysis of Variance
MathematicsThe methodology carried out in this work is based on non-parametric inference. The problem is framed as a regression analysis, and the solution is derived using the permutation approach.
Stefano Bonnini +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Improved algorithm for permutation testing
Theoretical Computer Science, 2023 For a permutation $π: [K]\rightarrow [K]$, a sequence $f: \{1,2,\cdots, n\}\rightarrow \mathbb R$ contains a $π$-pattern of size $K$, if there is a sequence of indices $(i_1, i_2, \cdots, i_K ...
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Permutation Tests for Reflected Symmetry
Journal of Multivariate Analysis, 1998 A \(d\)-variate random variable \(x\) is said to be reflectedly symmetric about a center \(\mu\) if the imaginary part of the characteristic function of \(x-\mu\) equals zero, i.e., \[ E\biggl(\sin\bigl(t'(x-\mu)\bigl) \biggl) =0\quad \text{for }t \in\mathbb{R}^d, \tag{1} \] where \(t'\) stands for the transpose of \(t\).
Neuhaus, Georg, Zhu, Li-Xing
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Neuroinformatics, 2010 Cinema is a promising naturalistic stimulus that enables, for instance, elicitation of robust emotions during functional magnetic resonance imaging (fMRI).
Jukka-Pekka Kauppi +3 more
doaj +1 more source