Results 141 to 150 of about 141,402 (295)
Sorting signed permutations by transpositions and reversals [PDF]
, 2008 Large scale comparative genetic mapping offers exciting prospects for understanding genomic evolution and has recently become of interest in computational molecular biology. The genome rearrangement problem is the computational problem of determining the
Zhang, Fei.
core
The Möbius function of the consecutive pattern poset [PDF]
, 2011 An occurrence of a consecutive permutation pattern p in a permutation π is a segment of consecutive letters of π whose values appear in the same order of size as the letters in p.
Steingrimsson, E. +2 more
core +1 more source
The bireflections of a permutation
Discrete Mathematics, 1976 AbstractA bireflection of a permutation θ is an ordered pair (φ, ψ) of permutations satisfying φ2 = ψ2 = 1, θ = φψ. The family of bireflections of a permutation is studied. As a corollary an expression for the number of dihedral groups over θ in SA is obtained.
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
An Accept-and-Reject Algorithm to Sample from a Set of Permutations Restricted by a Time Constraint [PDF]
A modification of an accept-and-reject algorithm to sample from a set of restricted permutations is proposed. By concentrating on a special class of matrices obtained by restriction of the permutation in time, assuming the objects to be permuted to be ...
Johannes Hüsing
core
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1968 Summary The problem of generating random permutations of the integers 1, 2, …, n arises, for example, when sampling a randomization distribution and when tables of permutations are required for application to experimental design. An algorithm is described which minimizes the amount of randomization necessary to generate a random ...
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source