Results 61 to 70 of about 396,980 (268)

The enumeration of permutations avoiding 2143 and 4231 [PDF]

open access: yes, 2011
We enumerate the pattern class Av(2143, 4231) and completely describe its permutations.
Albert, M. H.   +2 more
core   +2 more sources

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

Pseudo-Permutations II: Geometry and Representation Theory [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2001
In this paper, we provide the second part of the study of the pseudo-permutations. We first derive a complete analysis of the pseudo-permutations, based on hyperplane arrangements, generalizing the usual way of translating the permutations. We then study
François Boulier   +3 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

On a mnemonic construction of permutations

open access: yesJournal of Mathematical Cryptology, 2017
In the past when only “paper and pencil” ciphers were in use, a mnemonic Bellaso’s method was applied to obtain a permutation from a meaningful phrase. It turns out that even nowadays this method and its variations are employed and provide a simple but ...
Antal Eugen, Grošek Otokar, Horak Peter
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Simple permutations poset

open access: yes, 2011
This article studies the poset of simple permutations with respect to the pattern involvement. We specify results on critically indecomposable posets obtained by Schmerl and Trotter to simple permutations and prove that if $\sigma, \pi$ are two simple ...
Adeline, Pierrot, Dominique, Rossin
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

An efficient crossover design for thorough QT studies / Ein effizientes Crossover-Design für klinische Studien zur Untersuchung des QT-Intervalls

open access: yesGMS Medizinische Informatik, Biometrie und Epidemiologie, 2010
Background: Thorough QT studies are typically a requirement of the clinical development program for new investigational drugs. These studies are a major cost factor in early development.
Ring, Arne   +3 more
doaj  

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