Results 61 to 70 of about 108,510 (269)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
GMS Medizinische Informatik, Biometrie und Epidemiologie, 2010 Background: Thorough QT studies are typically a requirement of the clinical development program for new investigational drugs. These studies are a major cost factor in early development.
Ring, Arne +3 more
doaj
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
A new generation tree for permutations, preserving the number of fixed points [PDF]
Discrete Mathematics & Theoretical Computer Science, 2014 We describe a new uniform generation tree for permutations with the specific property that, for most permutations, all of their descendants in the generation tree have the same number of fixed points.
Philippe Duchon, Romaric Duvignau
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
On Minimal Strings Containing the Elements of S_n by Decimation [PDF]
Discrete Mathematics & Theoretical Computer Science, 2001 The permutations by decimation problem is thought to be applicable to computer graphics, and raises interesting theoretical questions in combinatory theory.We present the results of some theoretical and practical investigation into this problem.We show ...
Robert Erra, Nik Lygeros, Nigel Stewart
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Surrogate Data Preserving All the Properties of Ordinal Patterns up to a Certain Length
Entropy, 2019 We propose a method for generating surrogate data that preserves all the properties of ordinal patterns up to a certain length, such as the numbers of allowed/forbidden ordinal patterns and transition likelihoods from ordinal patterns into others.
Yoshito Hirata +2 more
doaj +1 more source
Polyominoes determined by involutions [PDF]
Discrete Mathematics & Theoretical Computer Science, 2008 A permutomino of size n is a polyomino determined by particular pairs $(\pi_1, \pi_2)$ of permutations of length $n$, such that $\pi_1(i) \neq \pi_2(i)$, for $1 \leq i \leq n$.
Filippo Disanto, Simone Rinaldi
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Journal of Combinatorial Theory, Series A, 2004 Chung and Graham define quasirandom subsets of $\mathbb{Z}_n$ to be those with any one of a large collection of equivalent random-like properties. We weaken their definition and call a subset of $\mathbb{Z}_n$ $ε$-balanced if its discrepancy on each interval is bounded by $εn$.
openaire +3 more sources