Comparative transcriptome analysis of Peromyscus leucopus and C3H mice infected with the Lyme disease pathogen [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Lyme disease (LD), the most prevalent tick-borne disease of humans in the Northern Hemisphere, is caused by the spirochetal bacterium of Borreliella burgdorferi (Bb) sensu lato complex.
Alhussien M. Gaber +9 more
doaj +2 more sources
Lyme Disease Agent Reservoirs Peromyscus leucopus and P. maniculatus Have Natively Inactivated Genes for the High-Affinity Immunoglobulin Gamma Fc Receptor I (CD64) [PDF]
Pathogens, 2023 The abundant and widely distributed deermice Peromyscus leucopus and P. maniculatus are important reservoirs for several different zoonotic agents in North America.
Alan G. Barbour +2 more
doaj +2 more sources
Safety and immunogenicity of orally administered poxvirus vectored constructs in the white-footed mouse (Peromyscus leucopus) [PDF]
Vaccine: X, 2023 Globally, zoonotic spillover is becoming more frequent and represents a growing public health concern. Reservoir-targeted vaccination offers an intriguing alternative to traditional vaccine practices by establishing protection in wild populations that ...
Jordan T. Mandli +2 more
doaj +2 more sources
Differentiating Peromyscus leucopus bone marrow-derived macrophages for characterization of responses to Borrelia burgdorferi and lipopolysaccharide [PDF]
Infection and ImmunityCurrently, most tools utilized in host-pathogen interaction studies depend on the use of human or mouse (Mus musculus) cells and tissues. While these species have led to countless breakthroughs in our understanding of infectious disease, there are ...
Christopher C. Wells +6 more
doaj +2 more sources
Lactobacilli and other gastrointestinal microbiota of Peromyscus leucopus, reservoir host for agents of Lyme disease and other zoonoses in North America. [PDF]
PLoS ONE, 2020 The cricetine rodent Peromyscus leucopus is an important reservoir for several human zoonoses, including Lyme disease, in North America. Akin to hamsters, the white-footed deermouse has been unevenly characterized in comparison to the murid Mus musculus.
Ana Milovic +6 more
doaj +2 more sources
Modeling Powassan virus infection in Peromyscus leucopus, a natural host. [PDF]
PLoS Neglected Tropical Diseases, 2017 The tick-borne flavivirus, Powassan virus (POWV) causes life-threatening encephalitis in humans in North America and Europe. POWV is transmitted by ixodid tick vectors that feed on small to medium-sized mammals, such as Peromyscus leucopus mice, which ...
Luwanika Mlera +4 more
doaj +2 more sources
Acquired tick resistance in Peromyscus leucopus alters Ixodes scapularis infection [PDF]
Infection and ImmunityTicks are obligate hematophagous parasites and pathogen vectors responsible for morbidity and mortality worldwide. Ixodes scapularis is a vector for at least seven pathogens relevant to human and animal health, including the Lyme disease microbe ...
Elis A. Fisk +6 more
doaj +2 more sources
Peromyscus leucopus, Mus musculus, and humans have distinct transcriptomic responses to larval Ixodes scapularis bites [PDF]
Infection and ImmunityIxodes scapularis ticks are an important vector for at least seven tick-borne human pathogens, including a North American Lyme disease spirochete, Borrelia burgdorferi.
Jeffrey S. Bourgeois +11 more
doaj +2 more sources
Genomes, expression profiles, and diversity of mitochondria of the White-footed Deermouse Peromyscus leucopus, reservoir of Lyme disease and other zoonoses. [PDF]
Sci Rep, 2019 The cricetine rodents Peromyscus leucopus and P. maniculatus are key reservoirs for several zoonotic diseases in North America. We determined the complete circular mitochondrial genome sequences of representatives of 3 different stock colonies of P ...
Barbour AG +5 more
europepmc +4 more sources
Hematopoietic Aging Biomarkers in <i>Peromyscus leucopus</i> Mice. [PDF]
J Aging Sci, 2017 We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2-9 months), middle (22-23 months) and old (33-46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44+ cells in ...
Lin Z +4 more
europepmc +3 more sources