Coinfection ecology and pathogen emergence in a Borrelia-endemic landscape: 5 years of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti surveillance in Maryland [PDF]
Applied and Environmental MicrobiologyThe emergence of tick-borne pathogens depends on ecological opportunity and barriers to persistence within vectors and hosts. Borrelia burgdorferi is well established in the mid-Atlantic, whereas Babesia microti and Anaplasma phagocytophilum remain ...
Greg Joyner +7 more
doaj +2 more sources
Peromyscus leucopus, Mus musculus, and humans have distinct transcriptomic responses to larval Ixodes scapularis bites [PDF]
Infection and ImmunityIxodes scapularis ticks are an important vector for at least seven tick-borne human pathogens, including a North American Lyme disease spirochete, Borrelia burgdorferi.
Jeffrey S. Bourgeois +11 more
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Optimization of tissue sampling for Borrelia burgdorferi in white-footed mice (Peromyscus leucopus). [PDF]
PLoS ONE, 2020 Peromyscus leucopus (the white-footed mouse) is a known reservoir of the Lyme disease spirochete Borrelia burgdorferi. Sampling of white-footed mice allows for year-round B.
Sonya G Zawada +4 more
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Lentiviral Knockdown of Transcription Factor STAT1 in Peromyscus leucopus to Assess Its Role in the Restriction of Tick-borne Flaviviruses [PDF]
Bio-Protocol, 2017 Cellular infection with tick-borne flaviviruses (TBFVs) results in activation of the interferon (IFN) signaling pathway and subsequent upregulation of numerous genes termed IFN stimulated genes (ISGs) (Schoggins et al., 2011).
Adaeze Izuogu, R. Taylor
doaj +2 more sources
Hematopoietic Aging Biomarkers in <i>Peromyscus leucopus</i> Mice. [PDF]
J Aging Sci, 2017 We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2-9 months), middle (22-23 months) and old (33-46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44+ cells in ...
Lin Z +4 more
europepmc +3 more sources
Transplacental transmission of tick-borne Babesia microti in its natural host Peromyscus leucopus [PDF]
Parasites & Vectors, 2018 Background Babesia microti is an emerging tick-borne pathogen and the causative agent of human babesiosis. Mathematical modeling of the reproductive rate of B. microti indicates that it cannot persist in nature by horizontal tick-host transmission alone.
Danielle M. Tufts, Maria A. Diuk-Wasser
doaj +2 more sources
Evolution of Peromyscus leucopus mice in response to a captive environment. [PDF]
PLoS ONE, 2013 Many wildlife species are propagated in captivity as models for behavioral, physiological, and genetic research or to provide assurance populations to protect threatened species.
Robert C Lacy, Glen Alaks, Allison Walsh
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Hantavirus in rodents in the United States: Temporal and spatial trends and report of new hosts [PDF]
EcosphereIn North America, the rodent‐borne hantavirus pulmonary syndrome is predominantly caused by the Sin Nombre virus, typically associated with the deer mouse Peromyscus maniculatus.
Francisca Astorga +4 more
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Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to a Toll-like receptor agonist [PDF]
Frontiers in ImmunologyIntroductionThe white-footed deermouse Peromyscus leucopus is a primary reservoir for the agents of Lyme disease and other zoonoses in North America and manifests infection tolerance for the bacteria, protozoa, and viruses it hosts.
Jonathan V. Duong +7 more
doaj +2 more sources
The genome of Peromyscus leucopus, natural host for Lyme disease and other emerging infections. [PDF]
Sci Adv, 2019 The rodent Peromyscus leucopus is the natural reservoir of several tick-borne infections, including Lyme disease. To expand the knowledge base for this key species in life cycles of several pathogens, we assembled and scaffolded the P.
Long AD +7 more
europepmc +2 more sources