Interferon signaling in Peromyscus leucopus confers a potent and specific restriction to vector-borne flaviviruses. [PDF]
PLoS ONE, 2017 Tick-borne flaviviruses (TBFVs), including Powassan virus and tick-borne encephalitis virus cause encephalitis or hemorrhagic fevers in humans with case-fatality rates ranging from 1-30%. Despite severe disease in humans, TBFV infection of natural rodent
Adaeze O Izuogu +8 more
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Optimization of tissue sampling for Borrelia burgdorferi in white-footed mice (Peromyscus leucopus). [PDF]
PLoS ONE, 2020 Peromyscus leucopus (the white-footed mouse) is a known reservoir of the Lyme disease spirochete Borrelia burgdorferi. Sampling of white-footed mice allows for year-round B.
Sonya G Zawada +4 more
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Lentiviral Knockdown of Transcription Factor STAT1 in Peromyscus leucopus to Assess Its Role in the Restriction of Tick-borne Flaviviruses [PDF]
Bio-Protocol, 2017 Cellular infection with tick-borne flaviviruses (TBFVs) results in activation of the interferon (IFN) signaling pathway and subsequent upregulation of numerous genes termed IFN stimulated genes (ISGs) (Schoggins et al., 2011).
Adaeze Izuogu, R. Taylor
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Transplacental transmission of tick-borne Babesia microti in its natural host Peromyscus leucopus [PDF]
Parasites & Vectors, 2018 Background Babesia microti is an emerging tick-borne pathogen and the causative agent of human babesiosis. Mathematical modeling of the reproductive rate of B. microti indicates that it cannot persist in nature by horizontal tick-host transmission alone.
Danielle M. Tufts, Maria A. Diuk-Wasser
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Evolution of Peromyscus leucopus mice in response to a captive environment. [PDF]
PLoS ONE, 2013 Many wildlife species are propagated in captivity as models for behavioral, physiological, and genetic research or to provide assurance populations to protect threatened species.
Robert C Lacy, Glen Alaks, Allison Walsh
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A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine against Borrelia burgdorferi [PDF]
npj VaccinesLyme disease, caused by Borrelia burgdorferi and transmitted by Ixodes scapularis ticks, remains a significant vector-borne illness in the United States. Small mammal reservoirs, particularly Peromyscus leucopus, play a critical role in B.
Amy M. Schwartz +17 more
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Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to a Toll-like receptor agonist [PDF]
Frontiers in ImmunologyIntroductionThe white-footed deermouse Peromyscus leucopus is a primary reservoir for the agents of Lyme disease and other zoonoses in North America and manifests infection tolerance for the bacteria, protozoa, and viruses it hosts.
Jonathan V. Duong +7 more
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Comparison of arboreal behaviors in Peromyscus maniculatus gracilis and P. leucopus noveboracensis in northern Michigan. [PDF]
, 2010 MammalogyFor at least one hundred years, the deer mouse Peromyscus maniculatus and the white‐footed mouse P. leucopus have coexisted stably in northern Michigan, despite occupying similar ecological niches. It has been suggested that P. maniculatus and P.
McGuinness, Rory
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mBio, 2021 Animals that are natural carriers of pathogens that cause human diseases commonly manifest little or no sickness as a consequence of infection.
Gabriela Balderrama-Gutierrez +8 more
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Ecosphere, 2021 Mice belonging to the genus Peromyscus are one of the most important reservoirs of tick‐borne pathogens in the United States. However, the composition and abundance of Peromyscus species may vary geographically.
Ryan T. Larson +5 more
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