Interferon signaling in Peromyscus leucopus confers a potent and specific restriction to vector-borne flaviviruses. [PDF]
PLoS ONE, 2017 Tick-borne flaviviruses (TBFVs), including Powassan virus and tick-borne encephalitis virus cause encephalitis or hemorrhagic fevers in humans with case-fatality rates ranging from 1-30%. Despite severe disease in humans, TBFV infection of natural rodent
Adaeze O Izuogu +8 more
doaj +2 more sources
Lentiviral Knockdown of Transcription Factor STAT1 in Peromyscus leucopus to Assess Its Role in the Restriction of Tick-borne Flaviviruses [PDF]
Bio-Protocol, 2017 Cellular infection with tick-borne flaviviruses (TBFVs) results in activation of the interferon (IFN) signaling pathway and subsequent upregulation of numerous genes termed IFN stimulated genes (ISGs) (Schoggins et al., 2011).
Adaeze Izuogu, R. Taylor
doaj +2 more sources
Optimization of tissue sampling for Borrelia burgdorferi in white-footed mice (Peromyscus leucopus). [PDF]
PLoS ONE, 2020 Peromyscus leucopus (the white-footed mouse) is a known reservoir of the Lyme disease spirochete Borrelia burgdorferi. Sampling of white-footed mice allows for year-round B.
Sonya G Zawada +4 more
doaj +2 more sources
Transplacental transmission of tick-borne Babesia microti in its natural host Peromyscus leucopus [PDF]
Parasites & Vectors, 2018 Background Babesia microti is an emerging tick-borne pathogen and the causative agent of human babesiosis. Mathematical modeling of the reproductive rate of B. microti indicates that it cannot persist in nature by horizontal tick-host transmission alone.
Danielle M. Tufts, Maria A. Diuk-Wasser
doaj +2 more sources
Hantavirus in rodents in the United States: Temporal and spatial trends and report of new hosts [PDF]
EcosphereIn North America, the rodent‐borne hantavirus pulmonary syndrome is predominantly caused by the Sin Nombre virus, typically associated with the deer mouse Peromyscus maniculatus.
Francisca Astorga +4 more
doaj +2 more sources
Evolution of Peromyscus leucopus mice in response to a captive environment. [PDF]
PLoS ONE, 2013 Many wildlife species are propagated in captivity as models for behavioral, physiological, and genetic research or to provide assurance populations to protect threatened species.
Robert C Lacy, Glen Alaks, Allison Walsh
doaj +2 more sources
Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to a Toll-like receptor agonist [PDF]
Frontiers in ImmunologyIntroductionThe white-footed deermouse Peromyscus leucopus is a primary reservoir for the agents of Lyme disease and other zoonoses in North America and manifests infection tolerance for the bacteria, protozoa, and viruses it hosts.
Jonathan V. Duong +7 more
doaj +2 more sources
Emergence of <i>Ixodes scapularis</i> and <i>Borrelia burgdorferi</i>, the Lyme Disease Vector and Agent, in Ohio [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Lyme disease, the most common vector-borne disease in the United States, is caused by a tick-borne infection with Borrelia burgdorferi. Currently, Ohio is considered by the Centers for Disease Control and Prevention (CDC) to be non-endemic for Lyme ...
Peng eWang +6 more
doaj +3 more sources
Urbanization, Not Invasive Shrubs, Alters Tree Seed Fate by Modifying Rodent Activity [PDF]
Ecology and EvolutionChanges in the global environment are widespread and may have unappreciated effects on the activity of animals and the strength of animal‐mediated interactions.
Mark E. Fuka +2 more
doaj +2 more sources
Maternal transfer of oral vaccine induced anti-OspA antibodies protects Peromyscus spp. from tick-transmitted Borrelia burgdorferi [PDF]
Infection and ImmunityThe efficacy and duration of passive immunity protection depend on maternal antibody levels and transfer efficiency. We investigated whether oral vaccination of Peromyscus leucopus dams with recombinant outer surface protein A (OspA)-expressing ...
Jose F. Azevedo +4 more
doaj +2 more sources