Results 241 to 250 of about 853,052 (312)

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Induction and Marker Selection of Embryogenic-like Callus from the Hypocotyl of <i>Pinus thunbergii</i>. [PDF]

Plants (Basel)
Dai J, Gao L, Zhang M, Liu J, Meng P.
europepmc   +1 more source

THE INACTIVATION OF INVERTASE BY PEROXIDASE

Journal of Biological Chemistry, 1953
openaire   +2 more sources

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Discovery and Preclinical Characterization of NE-2-6 as a Potent Thyroid Peroxidase Inhibitor with Antithyroid Activity. [PDF]

Antioxidants (Basel)
Lee MG, Kang S, Kang HJ, Yun CW.
europepmc   +1 more source

2D Titanium-Based Nanozyme Induced a Ferroptosis-like Strategy for Triple-Negative Breast Cancer Therapeutics. [PDF]

Biomater Res
Yu H, Pi S, Jiang Z, Huang D, Yu X, Ye F, Yu T, Lan H, Zhang Q, Zhu J, Wu L, Nong Z, Huang Y, Huang Y.   +13 more
europepmc   +1 more source

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States. [PDF]

Glia
Baltar J, Abati R, Florido L, Holt MG.
europepmc   +1 more source

Plastic-Colonizing Fungi in the Eastern Mediterranean Sea: Community Structure and Physiological and Transcriptional Responses of <i>Aspergillus</i> to Pristine and Weathered PET. [PDF]

Int J Mol Sci
Itzahri SS, Popov D, Davidov K, Oren M.
europepmc   +1 more source

Engineering Catalytic Nanozymes for Antimicrobial Food Systems: Structure-Activity Relationships, Safe-by-Design Principles, and Industrial Translation. [PDF]

Nanomaterials (Basel)
Nguyen HL, Nguyen TBN.
europepmc   +1 more source