Results 341 to 350 of about 1,259,046 (413)

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

open access: yesAdvanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu   +12 more
wiley   +1 more source

Extracellular Vesicular Delta‐Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis

open access: yesAdvanced Science, EarlyView.
Small cell lung cancer (SCLC) harbors high molecular heterogeneity. Using a new liquid biopsy assay, SCLC subtypes can be identified by measuring mRNA of subtype transcription factors (ASCL1, POU2F3, and NEUROD1) in exosome‐rich extracellular vesicles. Combining with Delta‐like ligand 3 (DLL3) mRNA in exosomes and its membrane protein in extracellular ...
Hong Li   +27 more
wiley   +1 more source

Role of aspartate 42 and histidine 79 in the aiPLA<sub>2</sub> activity and oligomeric status of Prdx6 at low pH. [PDF]

open access: yesSci Rep
Kakchingtabam P   +9 more
europepmc   +1 more source

Recent trends and advances in single-atom nanozymes for the electrochemical and optical sensing of pesticide residues in food and water. [PDF]

open access: yesRSC Adv
Obaid Saleh R   +9 more
europepmc   +1 more source

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