Results 101 to 110 of about 299,721 (404)

Immunohistochemical pitfalls in the demonstration of insulin-degrading enzyme in normal and neoplastic human tissues [PDF]

open access: yesarXiv, 2007
Previously, we have identified the cytoplasmic zinc metalloprotease insulin-degrading enzyme(IDE) in human tissues by an immunohistochemical method involving no antigen retrieval (AR) by pressure cooking to avoid artifacts by endogenous biotin exposure and a detection kit based on the labeled streptavidin biotin (LSAB) method. Thereby, we also employed
arxiv  

Dynamics of protein-protein encounter: a Langevin equation approach with reaction patches [PDF]

open access: yes, 2008
We study the formation of protein-protein encounter complexes with a Langevin equation approach that considers direct, steric and thermal forces. As three model systems with distinctly different properties we consider the pairs barnase:barstar, cytochrome c:cytochrome c peroxidase and p53:MDM2.
arxiv   +1 more source

A large family of class III plant peroxidases.

open access: yesPlant and Cell Physiology, 2001
Class III plant peroxidase (POX), a plant-specific oxidoreductase, is one of the many types of peroxidases that are widely distributed in animals, plants and microorganisms.
S. Hiraga   +4 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

The role of peroxiredoxins in cancer [PDF]

open access: yes, 2017
Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22-27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite.
CAPALBO, CARLO   +4 more
core   +1 more source

Turning points in the evolution of peroxidase–catalase superfamily: molecular phylogeny of hybrid heme peroxidases

open access: yesCellular and Molecular Life Sciences, 2014
Heme peroxidases and catalases are key enzymes of hydrogen peroxide metabolism and signaling. Here, the reconstruction of the molecular evolution of the peroxidase–catalase superfamily (annotated in pfam as PF00141) based on experimentally verified as ...
M. Zámocký   +3 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

The Apoplastic Secretome of Trichoderma virens During Interaction With Maize Roots Shows an Inhibition of Plant Defence and Scavenging Oxidative Stress Secreted Proteins

open access: yesFrontiers in Plant Science, 2018
In Nature, almost every plant is colonized by fungi. Trichoderma virens is a biocontrol fungus which has the capacity to behave as an opportunistic plant endophyte.
Guillermo Nogueira-Lopez   +6 more
doaj   +1 more source

Biochemical and Pathological Studies on Peroxidases –An Updated Review

open access: yesGlobal Journal of Health Science, 2014
Peroxidases represent a family of isoenzymes actively involved in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases. Different types of peroxidases have organ, tissues, cellular and sub-cellular
A. Khan, A. Rahmani, Y. Aldebasi, S. Aly
semanticscholar   +1 more source

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