Results 281 to 290 of about 122,316 (341)

Genome-Wide Identification and Characterization of the Class III Peroxidase Gene Family in Radish (<i>Raphanus sativus</i>) with Insights into Their Roles in Anthocyanin Metabolism. [PDF]

Int J Mol Sci
Wei Z, Fu W, Liu X, Xu W, Chang L, Liu C, Wang S.   +6 more
europepmc   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Plant Defense Proteins: Recent Discoveries and Applications. [PDF]

Plants (Basel)
Shobade SO, Nilsen-Hamilton M, Zabotina OA.   +2 more
europepmc   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Hydrogen peroxide, ascorbate, and glutathione: building the Foyer-Halliwell-Asada pathway. [PDF]

Planta
Noctor G.
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Amide backbone chemical shift assignments for human glutathione peroxidase 4 I129S,L130S mutant (GPX4-U46C-I129S-L130S)

Bostock, Mark J., Mourao, Andre S.D., Popowicz, Grzegorz M., Sattler, Michael   +3 more
openalex   +1 more source

Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8. [PDF]

Biomolecules
Yang Y, Peng H, Meng D, Fa Z, Yao C, Lin X, Schick J, Jin X.   +7 more
europepmc   +1 more source

AlphaFold3-predicted model of full-length human Phospholipid hydroperoxide glutathione peroxidase GPX4 (UniProt P36969) containing selenocysteine residue

Luo, Shiqi; Liu, Xinnan; Wang, Xia; liu, Haotian; Ge, Wei
openalex   +1 more source