Results 131 to 140 of about 90,192 (259)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Spectrophotometric Evaluation of Laser-Assisted Dental Bleaching Using Erbium-Doped Yttrium Aluminum Garnet (Er:YAG) and Diode Lasers at Different Wavelengths: An In Vitro Study. [PDF]

Cureus
Alshibli EI, Hamadah OH, Hajeer MY.
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Examining Effects of Storage Duration on the Different Forms of Tocopherol and Peroxide Value in Walnut Kernel and Powder

Journal of Nuts
The walnut kernel (WK), which has high oil content and contains many polyunsaturated fatty acids (FFA), is considered a valuable nut with a protective effect against cardiovascular diseases.
Amir Hosseinvand, Bouchra Ikram Adja
doaj  

Salinity Tolerance and Antioxidant Response in Watermelon Seedlings Pre-Treated with Abiotic Stress Attenuators. [PDF]

Plants (Basel)
Leite MS, Torres SB, Benedito CP, Pereira KTO, Arruda MVM, Costa JCDO, Sousa GD, Cruz AAR, Bispo JPG, Alves CZ, Silva PFD, Porceddu M, Bacchetta G, Silva AÁD, Sá FVDS.   +14 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Quercetin parallels ascorbic acid in neuroprotection against manganese-induced toxicity in Drosophila melanogaster. [PDF]

BMC Complement Med Ther
Arogundade TT, Olatomide OD, Adeleye DA, Nwoke E, Adim VC, Omotefe A, Bayo-Olugbami AA, Omotoso DR, Gbadamosi I.   +8 more
europepmc   +1 more source

Convex polyhedral nanocrystals with high-index and low-index microfacets for electrochemical co-production of ozone and hydrogen peroxide

Chem Catalysis, 2023
Huaijie Shi, Ge Feng, Tulai Sun, Xiaosa Wang, Lei Ding, Zhi Wang, Hui Jin, Qiaoli Chen, Shibin Wang, Xing Zhong, Yihan Zhu, Jianguo Wang   +11 more
openaire   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Phthalimidoperoxycaproic Acid (PAP) Versus Peroxides and Impact on Dental Enamel After Whitening Treatment: An In Vitro Study. [PDF]

J Funct Biomater
Llena C, Saenz L, Ghilotti J, Folguera S, Melo M.   +4 more
europepmc   +1 more source