Results 151 to 160 of about 1,161,477 (260)

Arginase 2 deficiency mitigates sepsis‐associated acute kidney injury by alleviating lipid accumulation

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Spatiotemporal multi‐omics atlas reveals regional metabolic and proteomic specificity during sepsis‐to‐S‐AKI progression. 2. Arginine metabolism is central to S‐AKI pathogenesis, with declining arginine levels correlating with worsening renal function. 3. ARG2 upregulation in renal tubules and macrophages drives tubular lipid accumulation and kidney
Yu Xin, Yanqi Liu, Ning Zhang, Pengfei Huang, Qianqian Zhang, Yinghao Luo, Xinran Wang, Xiuhua Zhang, Tao Wu, Fengye Liu, Yu Xiao, Lifeng Shen, Weiting Zhang, Xibo Wang, Xianglin Meng, Yuping Bai, Xuan Wang, Nan Zhang, Qianghong Xu, Hongxue Meng, Xubin Zheng, Lixin Cheng, Kaijiang Yu, Changsong Wang   +23 more
wiley   +1 more source

Exploratory single‐nucleus multiomics analysis of myeloid cell states associated with neoadjuvant chemotherapy response in pancreatic ductal adenocarcinoma

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Neoadjuvant‐treated PDAC tumors were stratified into responders and non‐responders based on CAP guidelines snRNA‐seq, snATAC‐seq, and spatial transcriptomics can be used to profile the neoadjuvant‐chemotherapy‐treated PDAC immune landscape. Our exploratory findings nominate candidate myeloid features for validation in larger cohorts and functional ...
Mercy Ojetunde, Li Ma, Hillary G. Goodney, Alyson M. Stevens, Alan Mizener, Emidio E. Pistilli, Sascha Ott, Kawther Abdilleh, Barbara Szomolay, Gangqing Hu, Timothy D. Eubank, Brian A. Boone   +11 more
wiley   +1 more source

Protein Kinase C Promotes Peroxisome Biogenesis and Peroxisome-endoplasmic Reticulum Interaction

Peroxisomes carry out a diverse set of metabolic functions, including oxidation of very long-chain fatty acids, degradation of D-amino acids and hydrogen peroxide, and bile acid production.
Kaganovich, Daniel, Borisyuk, Anya, Amen, Triana, Howman, Charlotte, Pattabiraman, Sundararaghavan   +4 more
core   +1 more source

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti‐Inflammatory Effects but Upregulates HO‐1 and Alters Adiponectin Levels in Human Adipocytes

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro.
Johanna Matilainen, Sanni Foster, Viivi Berg, Janne Tampio, Tanja Turunen, Anne‐Mari Mustonen, Heikki Kyykallio, Maija Vaittinen, Ville Männistö, Jussi Pihlajamäki, Marjo Malinen, Sanna Oikari, Pirjo Käkelä, Dorota Kaminska, Veera Luukkonen, Kristiina M. Huttunen, Martin Wabitsch, Petteri Nieminen, Kirsi Rilla   +18 more
wiley   +1 more source

From Common Pathway to Divergent Diseases: Metabolic Aspects of Inborn Errors of CoA Biosynthesis

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Coenzyme A (CoA) biosynthesis is a conserved, dynamically regulated pathway essential for mitochondrial energy production, fatty acid oxidation, lipid biosynthesis and protein acylation. Biallelic variants in PANK2, PPCS, PPCDC, and COASY cause rare inborn errors of CoA biosynthesis, associated with markedly different clinical phenotypes ...
Ivano Di Meo, Yair Anikster, Valeria Tiranti, Arcangela Iuso   +3 more
wiley   +1 more source

38 | Effects of chronic treatment with conjugated linoleic acid on antioxidant gene expression and oxidative stress in sod1-g93a mouse model of amyotrophic lateral sclerosis

European Journal of Translational Myology
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor-neuron disorder strongly linked to oxidative stress. The degenerative process gradually impairs motor-neurons function and leads to loss of homeostasis and integrity of skeletal muscle.
Interuniversity Institute of Myology
doaj  

Pigmentary retinal dystrophy associated with peroxisome biogenesis disorder-Zellweger syndrome spectrum. [PDF]

Oxf Med Case Reports
Zou H, Sutherland L, Geddie B.
europepmc   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source