Results 161 to 170 of about 1,353,029 (249)
When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen +5 more
wiley +1 more source
A biomimetic 3D human skeletal muscle microtissue platform is developed by integrating primary young and aged SkMCs with muscle‐derived dECM and 3D‐printed PCL anchors. Aged constructs recapitulate selected biological and functional hallmarks of skeletal muscle aging, including impaired myotube formation, mitochondrial alterations, calcium handling ...
Sohae Yang +9 more
wiley +1 more source
Oxygenaging: A Physiological Framework for Geroscience
Mechanisms of aging disrupt oxygen homeostasis through three converging processes: oxygen‐cascade impairment, microvascular dysfunction, and molecular maladaptation. “Oxygenaging” integrates these domains to explain how declining oxygen delivery and utilization drive mitochondrial instability and amplify the effect of the hallmarks of aging.
Stefano Donega +6 more
wiley +1 more source
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma +1 more
wiley +1 more source

