Results 81 to 90 of about 1,353,029 (249)

Peroxisome biogenesis and maintenance in yeast [PDF]

, 2020
Peroxisomes are ubiquitous organelles in which eukaryotic cells compartmentalize a wide variety of metabolic processes. Among others, peroxisomes are involved in the metabolism of lipids and reactive oxygen species.
Wroblewska, Justyna
core   +12 more sources

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Peroxisome Quality Control Factors in Pexophagy and Peroxisome Biogenesis Disorders

, 2017
Peroxisome biogenesis disorders (PBDs) are metabolic disorders caused by the loss of peroxisomes. Most PBDs result from mutation in one of 3 genes that encode for the peroxisomal AAA ATPase complex (AAA-complex) that is required for cycling ubiquitinated-
Law, Kelsey Barton
core   +2 more sources

Peroxisome assembly: matrix and membrane protein biogenesis

, 2011
The biogenesis of peroxisomal matrix and membrane proteins is substantially different from the biogenesis of proteins of other subcellular compartments, such as mitochondria and chloroplasts, that are of endosymbiotic origin. Proteins are targeted to the
Suresh Subramani, Gaurav Agrawal, Changle Ma   +2 more
core   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Metabolomic Profiling Reveals Brain Lipid Alterations in PEX7-Deficient Models of Rhizomelic Chondrodysplasia Punctata

Biomolecules
Rhizomelic chondrodysplasia punctata type 1 (RCDP1) is a peroxisomal disorder characterized by skeletal shortening, intellectual disability, seizures, cataracts, and reduced lifespans. RCDP1 is caused by biallelic loss-of-function variants in PEX7, which
Riya Sankhe, Meredith I. Williams, Wedad Fallatah, Laura Mackay, Mary Layne Brown, Pranjali Bhagwat, Sarah H. Elsea, Nancy Braverman, Michael F. Wangler   +8 more
doaj   +1 more source

A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARα-dependent and -independent pathways

Journal of Lipid Research, 2005
Branched-chain fatty acids (such as phytanic and pristanic acid) are ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα) in vitro.
J. Gloerich, N. van Vlies, G.A. Jansen, S. Denis, J.P.N. Ruiter, M.A. van Werkhoven, M. Duran, F.M. Vaz, R.J.A. Wanders, S. Ferdinandusse   +9 more
doaj   +1 more source

Genome sequencing identifies a rare case of moderate Zellweger spectrum disorder caused by a PEX3 defect: Case report and literature review

Molecular Genetics and Metabolism Reports, 2020
Defects in PEX3 are associated with a severe neonatal-lethal form of Zellweger spectrum disorder. We report two moderately affected siblings whose clinical and biochemical phenotypes expand the reported spectrum of PEX3-related disease. Genome sequencing
Whiwon Lee, Gregory Costain, Susan Blaser, Susan Walker, Christian R. Marshall, Hernan Gonorazky, Michal Inbar-Feigenberg   +6 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor Alpha Target Genes [PDF]

, 2010
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
Rakhshandehroo, M., Rakhshandehroo, Maryam, Knoch, Bianca, Kersten, A.H., Müller, Michael, Bianca Knoch, Maryam Rakhshandehroo, Sander Kersten, Michael Müller, Knoch, B., Kersten, Sander, Müller, M.R.   +11 more
core   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source