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Peroxisome proliferator-activated receptors and angiogenesis
Nutrition, Metabolism and Cardiovascular Diseases, 2009The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPARalpha, PPARgamma and PPARdelta, encoded by different genes, and they form a subfamily of the nuclear receptor superfamily. The clinical interest in PPARs originates with fibrates and thiazolidinediones, which, respectively, act on PPARalpha and ...
F, Biscetti +5 more
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Peroxisome proliferator-activated receptors and inflammation
Pharmacology & Therapeutics, 2006Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptors family. PPARs are a family of 3 ligand-activated transcription factors: PPARalpha (NR1C1), PPARbeta/delta (NUC1; NR1C2), and PPARgamma (NR1C3). PPARalpha, -beta/delta, and -gamma are encoded by different genes but show substantial amino acid similarity ...
Leonardo A, Moraes +2 more
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Peroxisome Proliferator-Activated Receptors and Atherosclerosis
Angiology, 2011The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis.
Soskić, Sanja S +9 more
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Regulation of Peroxisome Proliferator-Activated Receptors
1998Publisher Summary This chapter describes the selected aspects of the current understanding about the workings of peroxisome proliferator-activated receptors (PPARs) and how they are regulated. The members of the nuclear receptor family regulate different aspects of development, differentiation, growth, homeostasis, and metabolism in the cell.
H N, Sørensen +2 more
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Peroxisome Proliferator Activated Receptors and Cannabinoids
2017Cannabinoids are a complex group of molecules that comprise phytocannabinoids, endocannabinoids and synthetic cannabinoids. Cannabinoids were initially identified by its ability to bind and activate the classical cannabinoid receptors CB1 and CB2.
Muñoz, E. +3 more
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Drugs targeting peroxisome proliferator-activated receptors
Drug Discovery TodayThe year 2024 witnessed the accelerated approvals of two peroxisome proliferator-activated receptor (PPAR) agonists for the treatment of primary biliary cholangitis (PBC). PPARs, including three isoforms (PPARα, PPARγ, and PPARδ), are therapeutic targets generating considerable debate yet also seeing significant advances in their successful targeting ...
Zhouling Xie +3 more
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Peroxisome proliferator activated receptors and obesity
European Journal of Pharmacology, 2002The peroxisome proliferator activated receptors (PPARs) are a group of ligand-activated transcription factors that govern numerous biological processes, including energy metabolism, cell proliferation, and inflammation. Three different PPAR isotypes can be distinguished: alpha, beta and gamma.
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Receptors | Peroxisome Proliferator-Activated Receptors
2021Mary C. Sugden +3 more
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Peroxisome proliferator activated receptors
Trends in Pharmacological Sciences, 2001Alex Elbrecht +2 more
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