Results 291 to 300 of about 250,000 (338)
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Peroxisome proliferator activated receptors and obesity
European Journal of Pharmacology, 2002The peroxisome proliferator activated receptors (PPARs) are a group of ligand-activated transcription factors that govern numerous biological processes, including energy metabolism, cell proliferation, and inflammation. Three different PPAR isotypes can be distinguished: alpha, beta and gamma.
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Peroxisome Proliferator Activated Receptors
2005The metabolic activity of the liver plays a central role in coordinating the supply of energy to peripheral organs, in particular the brain. It is at the heart of an adaptive system, which allows survival at times of food deprivation and governs the storage of excess energy when plenty of food is available.
Raphaël Genolet +2 more
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Peroxisome Proliferator-Activated Receptors
Journal of Biological Research and ReviewsPeroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate key physiological processes, including lipid metabolism, glucose homeostasis, and inflammation. The three subtypes, PPAR-alpha, PPAR-beta/delta, and PPAR-gamma, have distinct roles and tissue distributions, making them promising targets for metabolic and ...
Robert Ringseis, Klaus Eder
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Peroxisome proliferator-activated receptor ligands in atherosclerosis
Expert Opinion on Investigational Drugs, 2004In this review, the effect of peroxisome proliferator-activated receptor (PPAR) ligands on atherosclerosis is examined. The PPAR-gamma agonist thiazolidinediones are currently indicated for the management of Type 2 diabetes mellitus, and the PPAR-alpha agonist fibrates are used in dyslipidaemia.
Juan F, Viles-Gonzalez +3 more
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Peroxisome Proliferator‐activated Receptors: Stuctures and Function
Annals of the New York Academy of Sciences, 1996We have been attempting to elucidate the molecular mechanisms through which peroxisome proliferators exert their pleiotropic effects, with particular emphasis on understanding why humans appear unresponsive to these compounds. There is a wealth of data to implicate the peroxisome proliferator-activated receptor alpha (PPAR alpha) in mediating these ...
J D, Tugwood +4 more
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Transcription coactivators for peroxisome proliferator-activated receptors
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007Peroxisome proliferator-activated receptors (PPARs) regulate diverse biological processes such as development, differentiation, neoplastic conversion, inflammation and wound healing in addition to their critical roles in energy (lipid and carbohydrate) metabolism.
Songtao, Yu, Janardan K, Reddy
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The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Nature, 1998M. Ricote +4 more
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Drugs targeting peroxisome proliferator-activated receptors
Drug Discovery TodayThe year 2024 witnessed the accelerated approvals of two peroxisome proliferator-activated receptor (PPAR) agonists for the treatment of primary biliary cholangitis (PBC). PPARs, including three isoforms (PPARα, PPARγ, and PPARδ), are therapeutic targets generating considerable debate yet also seeing significant advances in their successful targeting ...
Zhouling Xie +3 more
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Peroxisome proliferator activated receptors and stroke
Current Atherosclerosis Reports, 2003Jean-Charles, Fruchart +2 more
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