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Reaction of Retinol with Peroxynitrite
Bioscience, Biotechnology, and Biochemistry, 2007The reactivity of retinol with peroxynitrite, which is a strong oxidant and has been reported to induce several biological damages, was investigated. 13-cis-14-nitroretinol (1), 13-trans-14-nitroretinol (2), 13-apo-beta-carotenone (3), retinal (4), 11,14-epoxyretinol (5), and 11,15-epoxyretinol (6) were identified as reaction products of retinol with ...
Rie, Suzuki +6 more
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Peroxynitrite: From interception to signaling
Archives of Biochemistry and Biophysics, 2016Peroxynitrite is a strong oxidant and nitrating species that mediates certain biological effects of superoxide and nitrogen monoxide. These biological effects include oxidative damage to proteins as well as the formation of 3-nitrotyrosyl moieties in proteins.
Bodo, Speckmann +3 more
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Peroxynitrite-induced cardiac myocyte injury
Free Radical Biology and Medicine, 1996The effects of peroxynitrite (ONOO-) on cultured cardiac myocytes were examined by simultaneous measurements of intracellular Ca2+ ([Ca2+]i) and contractile function. On exposure to 0.2 mM ONOO-, [Ca2+]i increased to beyond the systolic level within 5 min with a concomitant decrease in spontaneous contraction of myocytes followed by complete arrest ...
H, Ishida +4 more
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Peroxynitrite and drug-dependent toxicity
Toxicology, 2005Peroxynitrite is the product of the diffusion-controlled termination reaction between two radicals, nitric oxide and superoxide and is a strong oxidant and nitrating intermediate. Critical biomolecules like proteins, lipids and DNA react with peroxynitrite via direct or radical-mediated mechanisms, resulting in alterations in enzyme activities and ...
Ana, Denicola, Rafael, Radi
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Peroxynitrite Reaction with Heme Proteins
Nitric Oxide, 1999We have reported that low levels of peroxynitrite (PN) can cause inactivation of the heme-thiolate protein prostacyclin (PGI2)-synthase by nitration of a tyrosine residue. To prove that iron catalysis is involved we studied the interaction of PN with microperoxidase and P450nor, a heme-thiolate protein of known structure.
M, Mehl +4 more
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Effect of peroxynitrite on erythrocytes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1996The action of peroxynitrite on human erythrocytes and erythrocyte membranes was studied. Peroxynitrite (0.1-2 mM) induced a transient decrease of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythrocyte membrane acetylcholinesterase and ATPase activities.
M, Soszyński, G, Bartosz
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Peroxynitrite in airway diseases
Clinical & Experimental Allergy, 1998Sadeghi-Hashjin, G +4 more
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