Results 291 to 300 of about 84,481 (342)

Peroxynitrite and atherosclerosis

Biochemical Society Transactions, 1993
35. Connern, C. P. and Halestrap, A. P. (1992) Biochem. J. 284,381-385 36. Kay, J. E., Moore, A. L., Doe, S. E. A., Benzie, C. R., Schonbrunner, R., Schmid, F. X. and Halestrap, A. P. (1 990) Transplant Proc. 22,96-99 37. Bergsma, D. J., Eder, C., Gross, M., Kersten, H., Sylvester, D., Appelbaum, E., Cusimano, D., Livi, G. P., McLaughlin, M. M., Kasyan,
Annette Graham, Neil Hogg, Victor M. Darley-Usmar, Salvador Moncada   +3 more
openaire   +2 more sources

The Effects of Peroxynitrite on Erythrocytes

Clinical Chemistry and Laboratory Medicine, 2001
Endotoxin-induced peroxynitrite formation has been demonstrated in plasma. The aim of this study is to evaluate whether this has an effect on erythrocytes. For this purpose erythrocyte 3-nitrotyrosine (3-NT) level, Na+-K+ ATPase and glutathione peroxidase activities were measured both in vivo and in vitro. In vivo peroxynitrite formation was induced in
Unlu, A, Karabicak, U, Cimen, BEHZAT, Turkozkan, N, Ertabak, A   +4 more
openaire   +5 more sources

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.

American Journal of Physiology, 1996
Nitric oxide contrasts with most intercellular messengers because it diffuses rapidly and isotropically through most tissues with little reaction but cannot be transported through the vasculature due to rapid destruction by oxyhemoglobin.
J. Beckman, W. Koppenol
semanticscholar   +1 more source

Peroxynitrite—An ugly biofactor?

BioFactors, 2010
AbstractCellular damage occurring under oxidative conditions has been ascribed mainly to the formation of peroxynitrite (ONOOH/ONOO−) that originates from the reaction of NO•with O2•−. The detrimental effects of peroxynitrite are exacerbated by the reaction with CO2that leads to ONOOC(O)O−, which further decays to the strong oxidant radicals NO2•and ...
ASCENZI, Paolo, DI MASI, ALESSANDRA, SCIORATI C, CLEMENTI E.   +3 more
openaire   +5 more sources

Peroxynitrite Scavenging by Flavonoids

Biochemical and Biophysical Research Communications, 1997
The peroxynitrite scavenging activity of a series of structurally related flavonoids was tested. It was found that flavonoids are excellent scavengers of peroxynitrite. Compared to the known peroxynitrite scavenger ebselen, the most active flavonoids proved to be 10 times more effective.
Jos B. G. Paquay, Ronald E.M. Korthouwer, Aalt Bast, Guido R.M.M. Haenen   +3 more
openaire   +3 more sources

Biochemistry of Peroxynitrite and Protein Tyrosine Nitration.

Chemical Reviews, 2018
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-controlled reaction of the free radicals superoxide (O2•-) and nitric oxide (•NO).
G. Ferrer-Sueta, Nicolás Campolo, M. Trujillo, S. Bartesaghi, S. Carballal, N. Romero, B. Alvarez, R. Radi   +7 more
semanticscholar   +1 more source

Propofol Is a Peroxynitrite Scavenger

Anesthesia & Analgesia, 1997
P eroxynitrite is a potent oxidant formed by the rapid reaction between nitric oxide and superoxide radical (1). The peroxynitrite anion is relatively stable, but it can rapidly protonate to peroxynitrous acid, an unstable species, which decomposes with a half-life of about one second at pH 7.4 (1,2).
Demiryurek, AT, Kahraman, S
openaire   +4 more sources

Peroxynitrite: A Putative Cytotoxin

Pharmacology & Toxicology, 1998
Abstract:In recent years it has become apparent that peroxynitrite. which is one of the toxic metabolites originating from the reaction of nitric oxide and superoxide presents a number of pathologic states in which free radicals are thought to be involved.
Demiryurek, AT, Kanzik, I, Cakici, I
openaire   +4 more sources

Peroxynitrite and fibrinolytic system: The effect of peroxynitrite on plasmin activity

Molecular and Cellular Biochemistry, 2004
We have shown that peroxynitrite (ONOO-) inhibits streptokinase-induced conversion of plasminogen to plasmin in a concentration-dependent manner and reduces both amidolytic (IC5o approximately 280 microM at 10 microM concentration of enzyme) and proteolytic activity of plasmin.
Barbara Wachowicz, Joanna Kołodziejczyk, Pawel Nowak   +2 more
openaire   +3 more sources

Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring.

Analytical Chemistry, 2019
Drug-induced hepatotoxicity represents an important challenge for safety in drug development. The production of peroxynitrite (ONOO-) is proposed as an early sign in the progression of drug-induced hepatotoxicity.
Dandan Li, Shangfeng Wang, Zuhai Lei, Caixia Sun, A. M. El-Toni, M. Alhoshan, Yong Fan, Fan Zhang   +7 more
semanticscholar   +1 more source