Results 301 to 310 of about 84,481 (342)
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, 2018
The socio-economic, environmental, and health implications of diseases caused by pathogenic microorganisms and their treatment using conventional antimicrobials are significant.
Renwu Zhou +6 more
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The socio-economic, environmental, and health implications of diseases caused by pathogenic microorganisms and their treatment using conventional antimicrobials are significant.
Renwu Zhou +6 more
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Effect of peroxynitrite on erythrocytes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1996The action of peroxynitrite on human erythrocytes and erythrocyte membranes was studied. Peroxynitrite (0.1-2 mM) induced a transient decrease of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythrocyte membrane acetylcholinesterase and ATPase activities.
Grzegorz Bartosz, Mirosław Soszyński
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The Reaction of Peroxynitrite with Zeaxanthin
Nitric Oxide, 1998The oxygenated carotenoids zeaxanthin and lutein, found in the macular area of the retina, may offer protection against or repair of oxidative damage associated with the degenerative diseases of aging. Since both superoxide and nitrogen monoxide, which react to form peroxynitrite, are found in the retina, we studied the reaction of peroxynitrite with ...
Patricia L. Bounds +3 more
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Bactericidal activity of peroxynitrite
Archives of Biochemistry and Biophysics, 1992Peroxynitrite is a strong oxidant formed by macrophages and potentially by other cells that produce nitric oxide and superoxide. Peroxynitrite was highly bactericidal, killing Escherichia coli in direct proportion to its concentration with an LD50 of 250 microM at 37 degrees C in potassium phosphate, pH 7.4.
Ling Zhu +2 more
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Peroxynitrite: cellular pathology and implications in autoimmunity
Journal of immunoassay & immunochemistry, 2019In inflamed tissues, the reaction of nitric oxide and superoxide leads to the formation of an extremely reactive peroxynitrite (ONOO−), which is a well known oxidizing and nitrating agent that exhibits high reactivity at physiological pH.
R. Ahmad, Ahtesham Hussain, H. Ahsan
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The Reaction of Ebselen with Peroxynitrite
Chemical Research in Toxicology, 1996Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one, rapidly reacts with peroxynitrite, the rate constant being of the order of 10(6) M-1 s-1; the reaction yields the selenoxide of the parent molecule, 2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide, as the sole selenium-containing product; a stoichiometry of 1 mol of ebselen reacted and of the selenoxide
Helmut Sies, Hiroshi Masumoto
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Journal of the American Chemical Society, 2016
Peroxynitrite (OONO(-)) is profoundly implicated in health and disease. The physiological and pathological outcome of OONO(-) is related to its local concentration, and hence, a reliable OONO(-) assay is highly desired.
X. Jia +7 more
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Peroxynitrite (OONO(-)) is profoundly implicated in health and disease. The physiological and pathological outcome of OONO(-) is related to its local concentration, and hence, a reliable OONO(-) assay is highly desired.
X. Jia +7 more
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General Pharmacology: The Vascular System, 1998
1. Peroxynitrite is a short-lived and damaging oxidant that forms rapidly from the reaction of superoxide with nitric oxide. 2. In 1990, Joseph Beckman proposed that peroxynitrite contributed significantly to pathological oxidative stress in living tissues, and subsequent evidence strongly supports this proposal. 3.
Michael A. Packer +3 more
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1. Peroxynitrite is a short-lived and damaging oxidant that forms rapidly from the reaction of superoxide with nitric oxide. 2. In 1990, Joseph Beckman proposed that peroxynitrite contributed significantly to pathological oxidative stress in living tissues, and subsequent evidence strongly supports this proposal. 3.
Michael A. Packer +3 more
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Effects of Lazaroids And A Peroxynitrite Scavenger In A Cell Model Of Peroxynitrite Toxicity
Free Radical Biology and Medicine, 1997We developed a cerebellar granule cell model of peroxynitrite toxicity and showed that certain sulfhydryl-containing compounds (e.g., penicillamine) present as concurrent treatments could inhibit this toxicity. In the present study, 21-aminosteroid and pyrrolopyrimidine lazaroids were tested for cytoprotection in this peroxynitrite toxicity model.
John S. Althaus +2 more
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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide.
American Journal of Physiology, 1995Nitric oxide and superoxide, which are produced by several cell types, rapidly combine to form peroxynitrite. This reaction can result in nitric oxide scavenging, and thus mitigation of the biological effects of superoxide.
W. Pryor, G. Squadrito
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