Results 321 to 330 of about 84,481 (342)
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Journal of the American Chemical Society, 2015
Accumulating evidence suggests that formation of peroxynitrite (ONOO(-)) in the cerebral vasculature contributes to the progression of ischemic damage, while the underlying molecular mechanisms remain elusive.
Xin Li +11 more
semanticscholar +1 more source
Accumulating evidence suggests that formation of peroxynitrite (ONOO(-)) in the cerebral vasculature contributes to the progression of ischemic damage, while the underlying molecular mechanisms remain elusive.
Xin Li +11 more
semanticscholar +1 more source
Bioconjugate chemistry, 2016
Peroxynitrite is a prominent biological reactive nitrogen species from radical combination of nitric oxide and superoxide and fundamentally involved in broad spectrum physiological and pathological processes.
Quanjuan Zhang +4 more
semanticscholar +1 more source
Peroxynitrite is a prominent biological reactive nitrogen species from radical combination of nitric oxide and superoxide and fundamentally involved in broad spectrum physiological and pathological processes.
Quanjuan Zhang +4 more
semanticscholar +1 more source
Reactions between Nitric Oxide, Superoxide, and Peroxynitrite: Footprints of Peroxynitrite in Vivo
1995Publisher Summary This chapter examines a number of reaction pathways for nitric oxide, with the emphasis on assessing their biological relevance. Till date, the fastest reaction for nitric oxide with clear toxicological significance is that with superoxide to produce ONOO − . Thus, the chemistry and reactivity of ONOO − are discussed at length.
John P. Crow, Joseph S. Beckman
openaire +3 more sources
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide.
Chemical Research in Toxicology, 1992Peroxynitrite [oxoperoxonitrate(1-), ONOO-] may be formed in vivo from superoxide and nitric oxide. The anion is stable, but the acid (pKa = 6.8) decays to nitrate with a rate of 1.3 s-1 at 25 degrees C.
W. Koppenol +4 more
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[32] Defenses against peroxynitrite
1999Stimulated inflammatory cells produce superoxide and nitric oxide radicals, which react, in a fast reaction, to generate peroxynitrite. Biological systems require protection against this reactive species, which leads to DNA damage by oxidizing guanine and by causing single-strand breaks and to tyrosine nitration, potentially interfering with ...
Lars-Oliver Klotz +2 more
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, 2015
The quantification of peroxynitrite (ONOO−, PON) and hydrogen peroxide (H2O2) is intrinsically difficult as both species show similar oxidative features located within a narrow potential. The sub-second lifetime of ONOO− at neutral pH further complicates
I. Hosu +11 more
semanticscholar +1 more source
The quantification of peroxynitrite (ONOO−, PON) and hydrogen peroxide (H2O2) is intrinsically difficult as both species show similar oxidative features located within a narrow potential. The sub-second lifetime of ONOO− at neutral pH further complicates
I. Hosu +11 more
semanticscholar +1 more source
Peroxynitrite and Cell Signaling
1997Highly reactive oxidants such as the hydroxyl radical are generally assumed to cause random cellular damage, which presumably results in cellular necrosis. However, signal transduction pathways in cells respond to many extracellular signals including oxidative stress.
Rafael Radi +3 more
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Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Nature reviews. Drug discovery, 2007C. Szabó, H. Ischiropoulos, R. Radi
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Peroxynitrite in airway diseases
Clinical & Experimental Allergy, 1998Henricks +4 more
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