Results 41 to 50 of about 245,869 (224)
Newspaper of the university of alaska southeast juneau campus [PDF]
, 1990 Southeast student government unite during conference -- Pool table pleases some students, upsets others -- Gorbachev accepts honorary degree -- Regents approve future tuition increases -- Juneau housing shortage affecting UAS students -- Skagway's ...
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Clay-kickers of Flanders Fields: Canadian Tunnellers at Messines Ridge 1916-1917 [PDF]
, 2018 This article explores the Canadian tunnelling companies’ military mining organisation and accomplishments in underground galleries during the Great War.
Pascas, Brian
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Book Review: Grit: The Power of Passion and Perseverance
, 2017 I first stumbled across the research of Angela Duckworth after she was awarded the prestigious MacArthur Fellowship in 2013 for her work investigating the character traits that impact the achievement of long-term goals. So, when it was announced that she
Johnson, Matthew L.
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The Official Student Newspaper of UAS [PDF]
, 2015 Health Corner / First Friday -- Tidal Echoes -- Sweeney Todd / Whale Necropsy -- Calendar and ...
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Provenance research and Perseverance: the testimony of an archivist [PDF]
, 2014 Since the early 1990s elaborated research on looted WWII cultural assets has mainly focused on the war period and the immediate post-war years. The purpose was obvious and practical: documenting and facilitating restitution claims.
Vermote, Michel
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source