Results 151 to 160 of about 13,899 (258)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

A survey of in-memory key-value store implementation with various NVRAM Persistency model

, 2015
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Baek, Woongki, Nam, Beomseok, Kim, Wookhee   +2 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Going wild: prioritizing experimental models of rodent-borne viruses to decode zoonotic spillover and pandemic risk. [PDF]

J Virol
Honce R, Botten J.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Persistence of NPi differential predicts outcome at intensive care unit discharge: a single-center retrospective analysis. [PDF]

J Anesth Analg Crit Care
Zerbi SM, Martorana SM, Rana S, Locoselli F, Ferrari F, De Silvestri A, Privitera CM.   +6 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Nutritional strategies to improve lactation persistency in dairy ewes

, 2002
Milk production is largely dependent on the shape of the lactation curve. Relevant elements of the lactation pattern are the peak yield, which represents the maximum milk yield during the lactation, and the lactation persistency, which expresses the ...
Cannas, Antonello, Pulina, Giuseppe, Nudda, Anna   +2 more
core  

Anticipating volcanic eruptions using rescaled range analysis of volcano-tectonic seismicity. [PDF]

Sci Rep
Pérez-López R, Guardiola-Albert C, Felpeto A, Sanz-Mangas D, Méndez-Chazarra N, Abella R, Rodríguez-Pascua MA, López-Gutierrez J.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source