Results 71 to 80 of about 13,899 (258)
Prediction of natalizumab anti-drug antibodies persistency
, 2019 Background: Anti-drug antibodies (ADA) against natalizumab develop early during treatment. ADA persistency is defined by two consecutive positive results as performed by the current qualitative ELISA assay (positive/negative).
Anders Sjödin +30 more
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Persistency Semantics of the {I}ntel-x86 Architecture
, 2019 Emerging non-volatile memory (NVM) technologies promise the durability of disks with the performance of RAM. To describe the persistency guarantees of NVM, several memory persistency models have been proposed in the literature.
Wickerson, J. +7 more
core +1 more source
Journal of Crop Protection, 2018 The effects of four insecticides, abamectin (1500 and 750mgl-1), emamectin benzoate (1000 and 500mgl-1), acetamiprid (500 and 250mgl-1), and flubendiamide (500 and 250mgl-1), were studied on different preimaginal stages of T. brassicae and T. evanescens,
Sedighe Ashtari +2 more
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Extensive in vivo resilience of persistent Salmonella [PDF]
, 2012 Chronic infections caused by persistent pathogens represent an important health problem. Here, we establish a simple practical mouse Salmonella infection model for identifying bacterial maintenance functions that are essential for persistency.
Mazé, Alain +11 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Persistency of entanglement and nonlocality in multipartite quantum systems
, 2012 The behavior under particle loss of entanglement and nonlocality is investigated in multipartite quantum systems. In particular, we define a notion of persistency of nonlocality, which leads to device-independent tests of persistent entanglement.
Brunner, Nicolas, Vertesi, Tamas
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source