Results 71 to 80 of about 16,153 (254)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Testing for Yield Persistency: Is It Skill or is It Luck? [PDF]
This study uses corn yield data from McLean County, Illinois to test whether farmer skill influences yields. This analysis is conducted by performing persistency tests on unadjusted, soil productivity adjusted (PA), and productivity and input intensity ...
Schnitkey, Gary D. +3 more
core
The role of regional context on innovation persistency of firms
, 2018 This paper analyses the role of regional context on innovation persistency of firms. Using the Community Innovation Survey in Sweden, we have traced firms' innovative behaviour from 2002 to 2012, in terms of four Schumpeterian types of innovation ...
Karlsson, Charlie, +2 more
core +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Genetics of lactation persistency
, 1999 peer reviewedLactation persistency, often simply called persistency, in general can be defined as the ability to maintain yields during the lactation. Persistency has an impact on feed costs, health, and fertility.
Swalve, H. H., Gengler, Nicolas
core
Revista Brasileira de Zootecnia, 2011 Procurou-se avaliar a precisão de cinco modelos não-lineares em descrever a forma da curva de produção de leite de vacas Nelore e o efeito do consumo voluntário (CV) da vaca e do bezerro sobre a produção de leite (PL). Foram testados os modelos de Sikka,
Lara Toledo Henriques +5 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Prediction of natalizumab anti-drug antibodies persistency
, 2019 Background: Anti-drug antibodies (ADA) against natalizumab develop early during treatment. ADA persistency is defined by two consecutive positive results as performed by the current qualitative ELISA assay (positive/negative).
Anders Sjödin +30 more
core +2 more sources
Majalah Kedokteran Gigi Indonesia, 2013 Impaksi gigi terjadi karena gigi gagal untuk erupsi secara sempurna pada posisinya akibat terhalang oleh gigi lain maupun jaringan lunak atau padat di sekitarnya.
Apreka Tigor Kusumasmara +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source